Microfluidic mixing device

Patent metadata

Field	Value
Publication number	US-10286366-B2
Application number	US-201214407005-A
Country	US
Kind code	B2
Filing date	Sep 24, 2012
Priority date	Sep 24, 2012
Publication date	May 14, 2019
Grant date	May 14, 2019

Abstract

In one embodiment, a microfluidic mixing device includes a mixing channel, a fluid inlet chamber to pass fluids into the mixing channel, an axis-asymmetric mixing actuator integrated within the channel to cause fluid displacements that mix the fluids as they flow through the channel, and an outlet chamber to receive the mixed fluids.

First claim

What is claimed is:

1. A microfluidic mixing device comprising:
a mixing channel;
a fluid inlet chamber to pass fluids into the mixing channel, the mixing channel having a unidirectional fluid flow therethrough;
a pump actuator located symmetrically on a center axis of the mixing channel;
an axis-asymmetric mixing actuator integrated within the mixing channel to cause fluid displacements that mix the fluids as they flow through the mixing channel, the axis-asymmetric mixing actuator including at least two resistors to produce steam bubbles when activated;
an outlet chamber to receive the mixed fluids; and
a controller to alternatingly activate the at least two resistors to generate fluid displacements with the steam bubbles to create a wiggling fluid path through the mixing channel,
wherein the pump actuator causes a fluid flow through the mixing channel in a direction from the fluid inlet chamber to the outlet chamber.

2. A microfluidic mixing device as in claim 1 , wherein a width of the fluid inlet chamber is larger than a width of an entrance to the mixing channel.

3. A microfluidic mixing device as in claim 1 , wherein the axis-asymmetric mixing actuator comprises the at least two resistors located on a first side of the mixing channel and staggered along a length of the mixing channel.

4. A microfluidic mixing device as in claim 1 , wherein the at least two resistors include a first resistor on a first side of the mixing channel and a second resistor on an opposite side of the mixing channel and co-located along the length of the mixing channel with respect to the first resistor.

5. A microfluidic mixing device as in claim 3 , further comprising a resistor on an opposite side of the mixing channel and staggered along the length of the mixing channel with respect to the at least two resistors located on a first side of the mixing channel.

6. A microfluidic mixing device as in claim 1 , wherein the axis-asymmetric mixing actuator comprises the at least two resistors being on different sides of the mixing channel and co-located along the length of the mixing channel.

7. A microfluidic mixing device as in claim 1 , wherein the axis-asymmetric mixing actuator comprises the at least two resistors being on different sides of the mixing channel and staggered along the length of the mixing channel.

8. A microfluidic mixing system comprising:
a microfluidic mixing device comprising a fluid mixing channel;
a fluid pump to pump fluids through the mixing channel;
axis-asymmetric mixing actuators integrated within the mixing channel to mix fluids as they flow through the mixing channel, at least one of the axis-asymmetric mixing actuators including at least two resistors to produce steam bubbles when activated; and
a controller coupled to the axis asymmetric mixing actuators, the controller being to:
alternatively activate the at least two resistors to generate fluid displacements with the steam bubbles to create a wiggling fluid path through the mixing channel.

9. A microfluidic mixing system as in claim 8 , wherein the fluid pump is selected from the group consisting of an external fluid pump and a pump actuator integrated within the mixing channel at a center axis of the mixing channel and toward one end of the mixing channel.

10. A microfluidic mixing system as in claim 8 , further comprising a controller to control a sequence and a timing of activations of the at least two resistors.

11. The microfluidic mixing device as in claim 4 , wherein the controller is to alternatingly activate the axis-asymmetric mixing actuator by activating the first resistor for a preset time duration followed by an activation of the second resistor for another preset time duration.

Assignees

• Hewlett Packard Development Co

Inventors

• Govyadinov Alexander
• Torniainen Erik D
• Markel David P
• Kornilovich Pavel

Classifications

• B01L2300/0867

  Multiple inlets and one sample wells, e.g. mixing, dilution · CPC title

• B01L3/50273

  characterised by the means or forces applied to move the fluids · CPC title

• B01F11/0071

  Operations & Transport · mapped topic

• B01F15/00493

  Operations & Transport · mapped topic

• B01F5/12 Primary

  Operations & Transport · mapped topic