Intraocular lenses

Patent metadata

Field	Value
Publication number	US-10286106-B2
Application number	US-201615157260-A
Country	US
Kind code	B2
Filing date	May 17, 2016
Priority date	Mar 7, 2011
Publication date	May 14, 2019
Grant date	May 14, 2019

Abstract

A shape memory polymer (SMP) intraocular lens may have a refractive index above 1.45, a Tg between 10° C. and 60° C., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum. The intraocular lens is then rolled at a temperature above Tg of the SMP material. The intraocular device is radially compressed within a die to a diameter of less than or equal to 1.8 mm while maintaining the temperature above Tg. The compressed intraocular lens device may be inserted through an incision less than 2 mm wide in a cornea or sclera or other anatomical structure. The lens can be inserted into the capsular bag, the ciliary sulcus, or other cavity through the incision. The SMP can substantially achieve refractive index values of greater than or equal to 1.45.

First claim

What is claimed is:

1. An intraocular lens comprising:
a refractive index above 1.45;
a glass transition temperature (Tg) between 10° C. and 60° C., inclusive;
de minimis or an absence of glistening; and
substantially 100% transmissivity of light in the visible spectrum,
wherein the intraocular lens comprises a tert-butyl acrylate (tBA) monomer,
and wherein the intraocular lens comprises a crosslinking monomer selected from the group consisting of: poly(ethylene glycol) diacrylate with a molecular weight substantially between 500 and 2000, inclusive; and poly(ethylene glycol) dimethacrylate (PEGDMA) with a molecular weight substantially between 500 and 2000, inclusive.

2. The intraocular lens of claim 1 , wherein the intraocular lens is formed from a combination of 50 weight percent tert-butyl acrylate monomers, 28 weight percent isobutyl acrylate monomers, and 22 weight percent PEGDMA 1000 crosslinking monomers.

3. The intraocular lens of claim 1 , wherein the intraocular lens is formed from a combination of 78 weight percent tert-butyl acrylate monomers and 22 weight percent PEGDMA 1000 crosslinking monomers.

4. The intraocular lens of claim 1 , wherein the intraocular lens is formed from a combination of 65 weight percent tert-butyl acrylate monomers, 13 weight percent butyl acrylate monomers, and 22 weight percent PEGDMA 1000 crosslinking monomers.

5. The intraocular lens of claim 1 , wherein the crosslinking monomer is PEGDMA 1000.

6. The intraocular lens of claim 1 , further comprising a n-butyl acrylate (nBA) monomer.

7. The intraocular lens of claim 1 , further comprising a photo-initiator.

8. The intraocular lens of claim 1 , further comprising a n-butyl acrylate (nBA) monomer and a photo-initiator, and wherein the crosslinking monomer is PEGDMA 1000.

9. The intraocular lens of claim 1 , wherein the intraocular lens has a Tg between 15° C. and 45° C., inclusive.

10. The intraocular lens of claim 8 , wherein the intraocular lens has a Tg between 15° C. and 45° C., inclusive.

Assignees

• Univ Colorado Regents

Inventors

• Kahook Malik Y
• Mandava Naresh
• Shandas Robin
• Rech Bryan

Classifications

• B29C61/003

  characterised by the choice of material · CPC title

• A61L27/50

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61F2002/169

  Surrounding optic · CPC title

• B29L2031/7532

  Artificial members, protheses · CPC title

• A61F2/14

  Eye parts, e.g. lenses or corneal implants; Artificial eyes · CPC title