Composition comprising combined extracts of Schisandra fructus, Eucommiae cortex and Lycii fructus for preventing or treating metabolic bone diseases

Patent metadata

Field	Value
Publication number	US-10286025-B2
Application number	US-201615543436-A
Country	US
Kind code	B2
Filing date	Jan 15, 2016
Priority date	Jan 15, 2015
Publication date	May 14, 2019
Grant date	May 14, 2019

Abstract

The present invention provides a pharmaceutical composition or a food composition containing combined extracts comprising Schisandrae fructus, Eucommiae cortex and Lycii fructus as active ingredients for preventing or treating metabolic bone diseases. The composition of the present invention does not have side effects as it is a substance derived from natural sources; is effective on osteogenesis in ovariectomized mice; increases the bone content and the bone formation index of serum in real animal model; and reduces the bone resorption index so as to be useful for preventing or treating metabolic bone diseases.

First claim

The invention claimed is:

1. A method for preventing or treating metabolic bone diseases comprising administering a pharmaceutical composition consisting of combined extracts coming from a mixture of Schisandrae fructus, Eucommiae cortex and Lycii fructus as active ingredients to a subject in need.

2. The method according to claim 1 wherein a weight ratio of Schisandrae fructus, Eucommiae cortex and Lycii fructus is 1˜100:1˜100:1˜100.

3. The method according to claim 1 wherein the extract is extracted with an extraction solvent selected from a group consisting of alcohol, C 1 ˜C 4 alcohol, and a mixture thereof.

4. The method according to claim 1 wherein the metabolic bone diseases are selected from a group consisting of osteoporosis, osteopenia, osteomalacia, osteodystrophy and Paget's disease.

5. The method according to claim 4 wherein osteoporosis is postmenopausal osteoporosis.

6. The method according to claim 1 wherein the metabolic bone disease is osteoporosis.

7. The method of claim 1 , wherein the pharmaceutical composition further contains one or more additives.

8. A method for preventing or improving metabolic bone diseases by administering a food composition consisting of combined extracts coming from a mixture of Schisandrae fructus, Eucommiae cortex and Lycii fructus as active ingredients to a subject in need thereof.

9. The method according to claim 8 wherein the metabolic bone disease is osteoporosis.

10. The method according to claim 9 wherein osteoporosis is postmenopausal osteoporosis.

11. The method of claim 8 , wherein the food composition further contains one or more additives.

12. The method of claim 11 , wherein the additive is a sweetener.

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Yang Woong Mo
• Kim Mi Hye

Classifications

• A61K36/79 Primary

  Schisandraceae (Schisandra family) · CPC title

• A61K36/46

  Eucommiaceae (Eucommia family), e.g. hardy rubber tree · CPC title

• A61K36/815

  Lycium (desert-thorn) · CPC title

• A61K36/57

  Magnoliaceae (Magnolia family) · CPC title

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title