Sample introduction system

Patent metadata

Field	Value
Publication number	US-10281373-B2
Application number	US-201715643024-A
Country	US
Kind code	B2
Filing date	Jul 6, 2017
Priority date	May 4, 2012
Publication date	May 7, 2019
Grant date	May 7, 2019

Abstract

A sample port system/device associated with a fluid collection device is provided and is configured to receive fluid-containing devices of varying diameters. A method of improving the work flow and safety involved in acquiring and/or testing fluid samples using such sample port system/device is also provided.

First claim

What is claimed is:

1. A port comprising:
a) a first section having a frusto-conical shape, a first end with an internal diameter A, and a second end with an internal diameter B, wherein B is less than A;
b) a second section having a frusto-conical shape, a first end with an internal diameter C, a second end with an internal diameter D, a longitudinal axis extending from said first end to said second end, and a substantially circular internal surface along said longitudinal axis, wherein C is less than B, D is greater than C, and wherein said first end of said second section is adjacent to and in fluid flow communication with said second end of said first section;
c) a transition section having a frusto-conical shape, a first end with an inside diameter of D and a second end with an inside diameter E, wherein D is greater than E, wherein said first end of said transition section is adjacent to and in fluid flow communication with said second end of said second section;
d) a third section having a frusto-conical shape, a first end with an internal diameter E, a second end with an internal diameter F, a longitudinal axis extending from said first end to said second end, and a substantially circular internal surface along said longitudinal axis, wherein E is less than C, wherein F is greater than E, and wherein said first end of said third section is adjacent to and in fluid flow communication with said second end of said transition section;
e) a base section having a first end with a diameter G and a second end, wherein G is less than E, wherein said first end of said base section is adjacent to and in fluid flow communication with said second end of said third section.

2. The port of claim 1 wherein said second end of said base section is in fluid flow communication with an open inlet port of a fluid collection device selected from the group consisting of a microfluidic testing device and a multi or single use testing device.

3. The port of claim 2 wherein said second end of said base section is either fixedly or detachably connected in fluid flow communication with said open inlet port.

4. The port of claim 3 wherein the connection of said second end of said base section to said open inlet port is a circumferentially sealed connection.

5. The port of claim 2 configured to accept a fluid sample and pass said fluid sample to said microfluidic testing device through said open inlet port.

6. The port of claim 1 wherein said port is constructed of an elastomeric material.

7. The port of claim 1 wherein said first section is configured to accept and substantially seal the outer surface of a tip of a device having an outside diameter greater than B and less than A.

8. The port of claim 7 wherein said device is a syringe or test tube luer adaptor.

9. The port of claim 7 wherein said tip is substantially sealed at a location between said first and second ends of said first section.

10. The port of claim 1 wherein said second section is configured to accept and substantially seal the outer surface of a hollow tube having an outside diameter greater than or equal to C and less than D.

11. The port of claim 10 wherein said outer surface of said hollow tube is sealed at or near said first end of said second section.

12. The port of claim 11 wherein said transition section serves as a stop for said hollow tube.

13. The port of claim 1 wherein said transition section is configured to accept and substantially seal the outer surface of a hollow tube having an outside diameter greater than or equal to E and less than C.

14. The port of claim 13 wherein said outer surface of said hollow tube is sealed by the transition section.

15. The port of claim 14 wherein said first end of said base section serves as a stop for said hollow tube.

16. The port of claim 1 wherein said first end of said first section further comprises an outside surface having disposed thereon at least two tabs.

17. The port of claim 16 wherein said tabs are configured to receive at least one threaded portion of a syringe, thereby locking said syringe to said first end of said first section.

18. A microfluidic testing device comprising:
a) a first layer;
b) a second layer disposed above said first layer and defining an open inlet port;
c) a component located between said first and second layers, wherein said component is selected from the group consisting of a pump, a chamber, a capillary, a reagent, an analyzer, and combinations thereof;
d) a sample port comprising:
i) a first section having a frusto-conical shape having a first end with an internal diameter A and a second end with an internal diameter B, wherein B is less than A;
ii) a second section having a frusto-conical shape, a first end with an internal diameter C, a second end with an internal diameter D, a longitudinal axis extending from said first end to said second end, and a substantially circular internal surface along said longitudinal axis, wherein C is less than B, D is greater than C, and wherein said first end of said second section is adjacent to and in fluid flow communication with said second end of said first section;
iii) a transition section having a frusto-conical shape, a first end with an inside diameter of D and a second end with an inside diameter E, wherein D is greater than E, wherein said first end of said transition section is adjacent to and in fluid flow communication with said second end of said second section;
iv) a third section having a frusto-conical shape, a first end with an internal diameter E, a second end with an internal diameter F, a longitudinal axis extending from said first end to said second end, and a substantially circular internal surface along said longitudinal axis, wherein E is less than C, wherein F is greater than E, and wherein said first end of said third section is adjacent to and in fluid flow communication with said second end of said transition section;
v) a base section having a first end with a diameter G and a second end, wherein G is less than E, wherein said first end of said base section is adjacent to and in fluid flow communication with said second end of said third section; and

e) wherein said second end of said base section of said sample port is in fluid flow communication with said open inlet port.

19. A process for dispensing a fluid comprising:
a) utilizing the microfluidic testing device of claim 18 ;
b) inserting a fluid-containing device containing a fluid into said sample port until substantially sealed; and
c) transferring said fluid into said microfluidic testing device, between said first and second layers, through said open inlet port.

20. The process of claim 19 wherein said fluid-containing device is either a syringe or a test tube luer adaptor having a tip with a diameter greater than B and less than A, and wherein the outside surface of said tip is sealed within said first section upon insertion per step b).

21. The process of claim 20 wherein said fluid-containing device is a syringe, wherein said first end of said first section further comprises an outside surface having disposed thereon at least two tabs configured to receive at least one threaded portion of a syringe, and wherein said threaded portion of said syringe is engaged by twisting onto said tabs in order to lock said syringe to said first end of said first section.

22. The process of claim 19 wherein said fluid-containing device is a hollow tube having an outside diameter equal to or greater

Assignees

• Siemens Healthcare Diagnostics Inc

Inventors

• Rasmussen James E

Classifications

• G01N1/28 Primary

  Preparing specimens for investigation {including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q}(mounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 {; laboratory gas handling apparatus B01L5/00}) · CPC title

• B01L2300/123

  Flexible; Elastomeric · CPC title

• B01L3/502715 Primary

  characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces · CPC title

• B01L2200/023

  adapted for different sizes of tubes, tips or container · CPC title

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title