Mononucleotide-dithiocarbamate complex

Patent metadata

Field	Value
Publication number	US-10280187-B2
Application number	US-201816111884-A
Country	US
Kind code	B2
Filing date	Aug 24, 2018
Priority date	Apr 22, 2016
Publication date	May 7, 2019
Grant date	May 7, 2019

Abstract

Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

First claim

The invention claimed is:

1. A mononucleotide-dithiocarbamate gold complex, comprising:
a dithiocarbamate gold(I) compound represented by formula (I):

a salt thereof, a solvate thereof, or a combination thereof; and
at least one selected from the group consisting of adenosine-5′-monophosphate disodium salt (5′-AMP), cytidine-5′-monophosphate disodium salt (5′-CMP), guanosine-5′-monophosphate disodium (5′-GMP), and thymine-5′-monophosphate (5′-TMP), complexed to the gold(I) complex;
wherein R 1 and R 2 are alkyl groups independently selected from the group consisting of methyl, ethyl, and isopropyl;
R 3 , R 4 , and R 5 are independently selected from the group consisting of an optionally substituted C 1 -C 3 alkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted vinyl, an optionally substituted alkoxy, and an optionally substituted aryloxy; and
with the proviso that R 1 , R 2 , R 3 , R 4 , and R 5 are not each an ethyl.

2. The mononucleotide-dithiocarbamate gold complex of claim 1 , wherein R 1 and R 2 are the same unsubstituted alkyl group, and R 3 , R 4 , and R 5 are the same optionally substituted C 1 -C 3 alkyl group.

3. The mononucleotide-dithiocarbamate gold complex of claim 2 , wherein R 1 and R 2 are ethyls, and R 3 , R 4 , and R 5 are methyls.

4. A composition comprising:
the mononucleotide-dithiocarbamate gold complex of claim 1 ; and
a pharmaceutically acceptable carrier or excipient.

5. The composition of claim 4 , further comprising:
at least one chemotherapeutic agent selected from the group consisting of aflibercept, asparaginase, bleomycin, busulfan, carmustine, chlorambucil, cladribine, cyclophosphamide, cytarabine, dacarbazine, daunorubicin, doxorubicin, etoposide, fludarabine, gemcitabine, hydroxyurea, idarubicin, ifosfamide, irinotecan, lomustine, mechlorethamine, melphalan, mercaptopurine, methotrexate, mitomycin, mitoxantrone, pentostatin, procarbazine, topotecan, vinblastine, vincristine, retinoic acid, oxaliplatin, carboplatin, 5-fluorouracil, teniposide, amasacrine, docetaxel, paclitaxel, vinorelbine, bortezomib, clofarabine, capecitabine, actinomycin D, epirubicin, vindesine, methotrexate, 6-thioguanine, tipifarnib, imatinib, erlotinib, sorafenib, sunitinib, dasatinib, nilotinib, lapatinib, gefitinib, temsirolimus, everolimus, rapamycin, bosutinib, pzopanib, axitinib, neratinib, vatalanib, pazopanib, midostaurin, enzastaurin, trastuzumab, cetuximab, panitumumab, rituximab, bevacizumab, mapatumumab, conatumumab, and lexatumumab.

6. The mononucleotide-dithiocarbamate gold complex of claim 1 , wherein R 3 , R 4 , and R 5 are an C 1 -C 2 alkyl group.

7. The mononucleotide-dithiocarbamate gold complex of claim wherein R 1 and R 2 are methyls and R 3 , R 4 , and R 5 are ethyls.

Assignees

• Univ King Fahd Pet & Minerals
• Univ King Saud

Inventors

• Al-Jaroudi Said S
• Alhoshani Ali
• Altaf Muhammad
• Isab Anvarhusein Abdulkadir

Classifications

• G01N33/57515

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• A61K9/0053

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• G01N2800/52

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• A61N1/30

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