2-aminopyrimidine derivatives for the treatment of viral infections
US-9598378-B2 · Mar 21, 2017 · US
Macrocyclic purines for the treatment of viral infections
US10280180B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10280180-B2 |
| Application number | US-201314408681-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 12, 2013 |
| Priority date | Jul 13, 2012 |
| Publication date | May 7, 2019 |
| Grant date | May 7, 2019 |
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- Title
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- Abstract
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Abstract
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This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound having formula (I) or a pharmaceutically accepted salt thereof, wherein X is oxygen, NH, sulfur or Y is phenyl or pyridinyl, optionally substituted by one or more substituents independently selected from C 1-6 alkyl, C 1-4 alkoxy, trifluoromethyl or halogen, and Z is C 1-10 saturated or unsaturated alkyl optionally substituted by an alkyl or alkylhydroxyl; or Z is C 1-6 alkyl —NH—C(O)—C 1-6 alkyl- or C 1-6 alkyl —NH—C(O—C 1-6 alkyl —O—; or Z is C 1-10 alkyl —O— wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl; or Z is C 1-6 alkyl-O—C 1-6 alkyl- wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl; or Z is C 1-6 alkyl-O—C 1-6 alkyl-O— wherein said alkyl is unsaturated or saturated and can optionally be substituted by an alkyl or alkylhydroxyl. 2. A compound selected from the group consisting of: or a pharmaceutically acceptable salts thereof. 3. A pharmaceutical composition comprising a compound having formula (I) or a pharmaceutically acceptable salt thereof according to claim 1 and one or more pharmaceutically acceptable excipients, diluents or carriers. 4. A method of activating TLR7 in a subject comprising administering to the subject a therapeutically effective amount of a compound as claimed in claim 1 . 5. A pharmaceutical composition comprising a compound according to claim 2 and at least one pharmaceutically acceptable excipient, diluent or carrier. 6. A method of activating TLR7 in a subject comprising administering to the subject a therapeutically effective amount of a compound according to claim 2 . 7. A method of inducing interferon in a subject comprising administering to the subject a therapeutically effective amount of a compound of claim 1 . 8. A method of inducing interferon in a subject comprising administering to the subject a therapeutically effective amount of a compound of claim 2 .
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
Immunomodulators · CPC title
Antivirals · CPC title
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title
Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title
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Frequently asked questions
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- What does patent US10280180B2 cover?
- This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
- Who is the assignee on this patent?
- Janssen Sciences Ireland Uc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/52. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 07 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).