Support and packaging for membranes

Patent metadata

Field	Value
Publication number	US-10279974-B2
Application number	US-201514657535-A
Country	US
Kind code	B2
Filing date	Mar 13, 2015
Priority date	Mar 14, 2014
Publication date	May 7, 2019
Grant date	May 7, 2019

Abstract

A support assembly for supporting a biological product (e.g., membrane) in an operative position. The support assembly has a base and a cover. A membrane receiving portion of the base defines a plurality of perforations that extend between top and bottom surfaces of the product receiving portion. The cover is releasably coupled to the base in a product-covering position in which the cover overlies the product receiving portion of the base. In the operative position, the biological product engages the top surface of the product receiving portion and the bottom surface of the cover.

First claim

What is claimed is:

1. A membrane product package comprising:
a support assembly comprising:
a base having a longitudinal axis and comprising a product receiving portion, the product receiving portion having a top surface and an opposed bottom surface that are spaced apart relative to a vertical axis that is perpendicular to the longitudinal axis of the base, wherein the product receiving portion comprises a plurality of perforations extending between the top and bottom surfaces of the product receiving portion; and
a cover having a longitudinal axis, a top surface, and an opposed bottom surface, wherein the cover is configured for releasable coupling to the base in a product-covering position, and wherein, in the product-covering position, the cover overlies the product receiving portion of the base; and

a membrane positioned in an operative position between the product receiving portion of the base and the cover, wherein the membrane is a placental tissue product, wherein the membrane is positioned in engagement with at least a portion of the top surface of the product receiving portion of the base and at least a portion of the bottom surface of the cover, wherein the membrane is attached to the top surface of the product receiving portion of the base at at least one attachment point, and
wherein the base and the cover cooperate to support the membrane in the operative position.

2. The membrane product package of claim 1 , wherein the base further comprises a handling portion positioned adjacent to the product receiving portion relative to the longitudinal axis of the base.

3. The membrane product package of claim 2 , wherein, in the product-covering position, the cover does not overlap with the handling portion of the base.

4. The membrane product package of claim 1 , wherein in the product-covering position, the longitudinal axis of the cover is positioned in substantial alignment with the longitudinal axis of the base.

5. The membrane product package of claim 4 , wherein the product receiving portion of the base has a longitudinal length and a width, wherein the cover has a longitudinal length and a width, and wherein the longitudinal length of the cover is substantially equal to the longitudinal length of the product receiving portion.

6. The membrane product package of claim 5 , wherein the width of the cover is substantially equal to the width of the product receiving portion.

7. The membrane product package of claim 1 , wherein the cover has a plurality of corners, and wherein at least one of the corners of the cover is rounded.

8. The membrane product package of claim 7 , wherein the cover has four rounded corners.

9. The membrane product package of claim 8 , wherein the product receiving portion of the base has two rounded corners, and wherein, in the product-covering position, two rounded corners of the cover overlie the two rounded corners of the product receiving portion of the base.

10. The membrane product package of claim 1 , wherein the plurality of perforations of the product receiving portion of the base are substantially evenly distributed throughout the product receiving portion.

11. The membrane product package of claim 1 , wherein the plurality of perforations of the product receiving portion of the base are randomly distributed throughout the product receiving portion.

12. The membrane product package of claim 1 , wherein each perforation of the plurality of perforations has a respective diameter ranging from about 0.1 mm to about 5 mm.

13. The membrane product package of claim 1 , wherein each perforation of the plurality of perforations has a respective center point, and wherein the center points of neighboring perforations are spaced apart by a distance ranging from about 0.35 mm to about 10 mm.

14. The membrane product package of claim 1 , wherein the membrane is attached to the top surface of the product receiving portion of the base at at least three attachment points.

15. The membrane product package of claim 1 , wherein the top surface of the product receiving portion of the base is attached to the cover at at least one attachment point.

16. The membrane product package of claim 1 , wherein the cover is attached to the membrane at at least one attachment point.

17. The membrane product package of claim 16 , wherein the cover is attached to the membrane at at least two attachment points.

18. The membrane product package of claim 16 , wherein the top surface of the product receiving portion of the base is attached to the cover at at least one attachment point.

19. The membrane product package of claim 1 , wherein the top surface of the product receiving portion of the base is attached to the cover at at least one attachment point.

20. The membrane product package of claim 1 , wherein the membrane is a chorionic membrane product.

21. The membrane product package of claim 1 , wherein the membrane is an amniotic membrane product.

22. The membrane product package of claim 1 , wherein the membrane and the top surface of the product receiving portion of the base have sufficient surface traction to maintain the membrane in the operative position following removal of the cover from the base.

23. The membrane product package of claim 1 , wherein the membrane and the top surface of the product receiving portion of the base have a first surface traction, wherein the membrane and the cover have a second surface traction, and wherein the second surface traction is lower than the first surface traction.

24. A method of producing the membrane product package of claim 1 , comprising:
positioning the membrane in the operative position between the product receiving portion of the base and the cover, wherein the membrane is positioned in engagement with at least a portion of the top surface of the product receiving portion of the base and at least a portion of the bottom surface of the cover, wherein the step of positioning the membrane in the operative position comprises:
attaching the membrane to the top surface of the product receiving portion at at least one attachment point; and
releasably coupling the cover to the base in the product-covering position.

25. The method of claim 24 , wherein the step of positioning the membrane in the operative position further comprises:
attaching the membrane to the cover at at least one attachment point.

26. The method of claim 25 , wherein the method further comprises positioning the base, the membrane, and the cover within a cryopreservation solution, wherein the plurality of perforations of the product receiving portion provide contact between the membrane and the cryopreservation solution sufficient to cryopreserve the membrane.

27. A kit for repairing a tissue defect, comprising:
a container; and
a membrane product package positioned within the container, the membrane product package comprising:
a support assembly having:
a base having a longitudinal axis and comprising a product receiving portion, the product receiving portion having a top surface and an opposed bottom surface that are spaced apart relative to a vertical axis that is perpendicular to the longitudinal axis of the base, wherein the product receiving portion comprises a plurality of perforations extending between the top and bottom surfaces of the product receiving portion; and
a cover having a longitudinal axis, a top surface, and an opposed bottom

Assignees

• Osiris Therapeutics Inc

Inventors

• Duan-Arnold Yi
• Danilkovitch Alla
• Gyurdieva Alexandra
• Kuang Jin-Qiang
• Sinclair Steven Michael

Classifications

• B65D77/26 Primary

  Elements or devices for locating or protecting articles · CPC title

• B65B5/04

  Packaging single articles · CPC title

• A61F2/105

  Skin implants, e.g. artificial skin · CPC title

• A61B2090/0816

  for preventing adhesion · CPC title

• B65D65/02

  Wrappers or flexible covers · CPC title