Artificial scab for use in an airway

Patent metadata

Field	Value
Publication number	US-10279072-B2
Application number	US-201715645674-A
Country	US
Kind code	B2
Filing date	Jul 10, 2017
Priority date	Oct 27, 2010
Publication date	May 7, 2019
Grant date	May 7, 2019

Abstract

Body tissue and structures in an airway may be treated with an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body comprising a granular mixture of chitosan and polysaccharide particles. The artificial scab breaks apart into smaller pieces if peeled away from the surgical site or wound, thus reducing the risk of airway occlusion.

First claim

The invention claimed is:

1. A method comprising:
a) applying a substantially dry, free-flowing powdered mixture of about 10 to about 90 wt. % at least partially solvatable chitosan particles containing amino groups and about 90 to about 10 wt. % at least partially solvatable oxidized polysaccharide particles containing aldehyde groups to tissue or structure in a surgical site or wound in an airway moistened with blood, other bodily fluids or water, wherein substantially dry means the powder contains less than 10 wt. % water, and wherein the amino group functionality and molecular weight of the chitosan and the aldehyde group functionality and molecular weight of the oxidized polysaccharide are such that the particles adhere to such site or wound and to one another by inter-particle crosslinking reaction of amino groups on the chitosan particles with aldehyde groups on the polysaccharide particles, thereby
b) forming an artificial scab comprising an inhomogeneous, uncohesive, solid sheet-like body adhered to the tissue or structure, the body comprising a granular mixture of the chitosan and polysaccharide particles that breaks apart into smaller pieces when peeled away from the surgical site or wound.

2. A method according to claim 1 wherein the substantially dry, free-flowing powdered mixture contains less than 5 wt. % water.

3. A method according to claim 1 wherein upon application of the mixture to the surgical site or wound the chitosan particles and polysaccharide particles become at least partially solvated and at least partially react with one another.

4. A method according to claim 1 wherein upon application of the mixture to the surgical site or wound the chitosan particles and polysaccharide particles do not all become fully solvated, and instead retain at least part of the central portion of their original particulate structure in solid, undissolved form.

5. A method according to claim 1 further comprising irrigating the applied powdered mixture without removing significant quantities of the applied powder from the surgical site or wound.

6. A method according to claim 1 wherein the solid sheet-like body is not a hydrogel, and is not a translucent or transparent liquid covering.

7. A method according to claim 1 wherein the surgical site comprises a tonsillectomy site.

8. A method according to claim 1 wherein the solid sheet-like body has a residence time greater than 3 days.

9. A method according to claim 1 wherein the solid sheet-like body has a residence time less than 2 weeks.

10. A method according to claim 1 wherein the chitosan comprises a high molecular weight chitosan.

11. A method according to claim 1 wherein the chitosan comprises a salt.

12. A method according to claim 1 wherein the chitosan comprises a glutamate salt.

13. A method according to claim 1 wherein the oxidized polysaccharide comprises oxidized cellulose, chitin, chitosan, chondroitin sulfate, dextran, glycogen or hyaluronic acid.

14. A method according to claim 1 wherein the oxidized polysaccharide comprises oxidized starch.

15. A method according to claim 1 wherein the mixture contains about 30 to about 70 wt. % chitosan and about 70 to about 30 wt. % oxidized polysaccharide.

16. A method according to claim 1 wherein the mixture contains an antimicrobial agent.

17. A method according to claim 1 wherein the mixture contains an analgesic, anti-cholinergic, anti-fungal agent, antihistamine, steroidal or non-steroidal anti-inflammatory agent, anti-parasitic agent, antiviral agent, biostatic composition, chemotherapeutic or antineoplastic agent, cytokine, decongestant, additional hemostatic agent, immunosuppressor, mucolytic, nucleic acid, peptide, protein, steroid, vasoconstrictor, vitamin or mixture thereof.

18. A method according to claim 1 wherein the powdered mixture is sterilized and is provided in sealed packaging.

Assignees

• Medtronic Inc

Inventors

• Hissong James B
• Myntti Matthew F
• Medina Jennifer G

Classifications

• A61P41/00

  Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61P37/02

  Immunomodulators · CPC title

• A61P7/04

  Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title

• A61P35/00

  Antineoplastic agents · CPC title