Endovascular apparatus for perfusing organs in a body

Patent metadata

Field	Value
Publication number	US-10278384-B2
Application number	US-201415115623-A
Country	US
Kind code	B2
Filing date	Dec 2, 2014
Priority date	Feb 4, 2014
Publication date	May 7, 2019
Grant date	May 7, 2019

Abstract

In one representative embodiment, a method of perfusing organs in a patient's body is provided. The method comprises isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart and perfusing the visceral arteries, the visceral veins, and the abdominal organs with a perfusion fluid that is fluidly separated from the blood circulating through the patient's heart. While the visceral arteries and the visceral veins are isolated, and the visceral arteries, the visceral veins, and the abdominal organs are being perfused, the patient's blood is allowed to continue to circulate through the heart.

First claim

We claim:

1. A method of perfusing organs in a patient's body, the method comprising:
isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart;
perfusing the visceral arteries, the visceral veins, and the abdominal organs with a perfusion fluid that is fluidly separated from the blood circulating through the patient's heart;
while the visceral arteries and the visceral veins are isolated and the visceral arteries, the visceral veins, and the abdominal organs are being perfused, allowing the patient's blood to continue to circulate through the heart.

2. The method of claim 1 , wherein the act of perfusing the visceral arteries, the visceral veins, and the abdominal organs comprises establishing a flow of the perfusion fluid that flows into and through an arterial catheter placed in the patient's aorta, into and through the visceral arteries, the abdominal organs, and the visceral veins, and into and through a venous catheter placed in the patient's vena cava.

3. The method of claim 2 , wherein:
isolating the visceral arteries comprises inflating balloons on the arterial catheter to seal the balloons against the aorta wall upstream and downstream of the visceral arteries; and
isolating the visceral veins comprises inflating balloons on the venous catheter to seal the balloons against the vena cava wall upstream and downstream of the visceral veins.

4. The method of claim 2 , wherein the act of allowing the patient's blood to continue to circulate through the heart comprises shunting blood from the heart to flow into and through the arterial catheter, through a blood warmer, into and through the venous catheter, and back into the vena cava.

5. The method of claim 4 , wherein:
blood from the heart flows through a first lumen in the arterial catheter and through a first lumen in the venous catheter; and
the perfusion fluid flows through a second lumen in the arterial catheter, outwardly through side openings in the arterial catheter, inwardly through side openings in the venous catheter, and through a second lumen in the venous catheter.

6. The method of claim 4 , further comprising:
placing a first conduit into an artery of a lower extremity of the patient;
placing a second conduit into a vein of a lower extremity of the patient;
shunting a portion of blood from the arterial catheter to flow into and through the first conduit, into and through the vasculature of the patient's lower extremities, into and through the second conduit, and back into the venous catheter.

7. The method of claim 1 , wherein the perfusion fluid comprises a cold perfusion solution at a temperature of 4 degrees C. to 6 degrees C.

8. The method of claim 7 , wherein the perfusion solution comprises one or more of heparin, pentastarch, steroids, lactobionic acid, magnesium sulfate, raffinose, adenosine, allopurinol, glutathione, and potassium hydroxide.

9. The method of claim 1 , wherein the perfusion fluid comprises blood.

10. The method of claim 9 , wherein the blood being used as the perfusion fluid flows outside the body, is warmed and oxygenated, and then pumped back into the body.

11. The method of claim 1 , wherein the act of allowing the patient's blood to continue to circulate through the heart comprises shunting blood from the heart to flow into and through an arterial catheter placed in the patient's aorta, through a blood warmer, into and through a venous catheter placed in the patient's vena cava, and back into the vena cava.

12. The method of claim 1 , further comprising performing an explant procedure on the patient.

13. The method of claim 1 , wherein the act of isolating the visceral arteries and the visceral veins from blood circulating through the patient's heart comprises deploying a first perfusion stent in the patient's aorta and a second perfusion stent in the patient's vena cava, the first perfusion stent allowing blood from the heart to flow in a downstream direction from a location upstream of the abdominal organs to a location downstream of the abdominal organs without flowing into the visceral arteries, the second perfusion stent allowing blood in the vena cava to flow in a downstream direction from a location upstream of the abdominal organs to a location downstream of the abdominal organs without mixing with blood from the visceral veins.

14. The method of claim 13 , the act of perfusing the visceral arteries, the visceral veins, and the abdominal organs comprises establishing a flow of the perfusion fluid that flows into and through a first perfusion conduit having an outlet opening in communication with the visceral arteries, into and through the visceral arteries, the abdominal organs, the visceral veins, and into and through a second perfusion conduit having an inlet opening in communication with the visceral veins.

15. The method of claim 14 , wherein:
the first perfusion stent has enlarged end portions sealed against the inner wall of the aorta and an intermediate portion defining an arterial perfusion space between the inner wall of the aorta and the outer surface of the intermediate portion, the second perfusion stent has enlarged end portions sealed against the inner wall of the vena cava and an intermediate portion defining a venous perfusion space between the inner wall of the vena cava and the outer surface of the intermediate portion; and
the perfusion fluid flows through the first perfusion conduit, through the arterial perfusion space, through the visceral arteries, through the abdominal organs, through the visceral veins, through the venous perfusion space, and into the second perfusion conduit, in that order.

16. The method of claim 15 , wherein:
the first perfusion conduit has an end portion that extends through one of the enlarged end portions of the first perfusion stent; and
the second perfusion conduit has an end portion that extends through one of the enlarged end portions of the second perfusion stent.

17. A method of perfusing organs in a patient's body, the method comprising:
inserting an arterial catheter into the patient's aorta, the arterial catheter having a first lumen, a second lumen, and first and second balloons spaced apart along the length of the arterial catheter;
positioning the arterial catheter in the aorta such that the first balloon is upstream of the visceral arteries and the second balloon is downstream of the visceral arteries;
inserting a venous catheter into the patient's vena cava, the venous catheter having a first lumen, a second lumen, and first and second balloons spaced apart along the length of the venous catheter;
positioning the venous catheter in the vena cava such that the first balloon is upstream of the visceral veins and the second balloon is downstream of the visceral veins;
inflating the first and second balloons of the arterial and venous catheters, thereby isolating the visceral arteries and visceral veins from blood circulating through the patient's heart;
establishing a flow of a perfusion fluid that flows into and through the second lumen of the arterial catheter, into and through the visceral arteries, the abdominal organs, and the visceral veins, and into and through the second lumen of venous catheter; and
allowing blood from the heart to flow into and through the first lumen of the arterial catheter, and back into and through the first lumen of the venous catheter.

18. The method of claim 17 , wherein:
the arterial catheter comprises one or more side openings located between the balloons of the arterial catheter and perfus

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Tillman Bryan W
• Tevar Amit D
• Chun Youngjae

Classifications

• A01N1/0242

  Human Necessities · mapped topic

• A61M25/1011

  Multiple balloon catheters · CPC title

• A61M2025/1095

  with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft · CPC title

• A61B2017/1132

  End-to-end connections · CPC title

• A01N1/0247 Primary

  Human Necessities · mapped topic