Compositions to regulate renalase in the treatment of diseases and disorders

Patent metadata

Field	Value
Publication number	US-10273311-B2
Application number	US-201515321015-A
Country	US
Kind code	B2
Filing date	Jun 26, 2015
Priority date	Jun 26, 2014
Publication date	Apr 30, 2019
Grant date	Apr 30, 2019

Abstract

The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.

First claim

What is claimed is:

1. A composition comprising an isolated monoclonal antibody, wherein the antibody comprises: a) the heavy chain CDR1 sequence of SEQ ID NO:11; b) the heavy chain CDR2 sequence of SEQ ID NO:12; c) the heavy chain CDR3 sequence of SEQ ID NO:13; d) the light chain CDR1 sequence of SEQ ID NO:14; e) the light chain CDR2 sequence of SEQ ID NO:15; and f) the light chain CDR3 sequence of SEQ ID NO:16.

2. The composition of claim 1 , wherein the antibody specifically binds to renalase with an affinity of at least 10 −6 M.

3. The composition of claim 1 , wherein the antibody specifically binds a peptide sequence as set forth in SEQ ID NO:4.

4. The composition of claim 1 , wherein the antibody is selected from the group consisting of an immunoconjugate, a defucosylated antibody, and a bispecific antibody.

5. The composition of claim 4 , wherein the immunoconjugate comprises a therapeutic agent or a detection moiety.

6. The composition of claim 1 , wherein the antibody is selected from the group consisting of a humanized antibody, a chimeric antibody, a fully human antibody, and an antibody mimetic.

7. The composition of claim 1 , wherein the antibody comprises a heavy chain sequence as set forth in SEQ ID NO:9.

8. The composition of claim 1 , wherein the antibody comprises a light chain sequence as set forth in SEQ ID NO:10.

Assignees

• Univ Yale

Inventors

• Desir Gary
• Hunt Abigail
• O-Rear Jessica
• Flynn Peter

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P1/18

  for pancreatic disorders, e.g. pancreatic enzymes · CPC title

• A61P13/12

  of the kidneys · CPC title