Cancer cell-containing composition

Patent metadata

Field	Value
Publication number	US-10273257-B2
Application number	US-201816112358-A
Country	US
Kind code	B2
Filing date	Aug 24, 2018
Priority date	Apr 22, 2016
Publication date	Apr 30, 2019
Grant date	Apr 30, 2019

Abstract

Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

First claim

The invention claimed is:

1. A cancer cell composition, comprising:
a gold(I) complex represented by formula (I):

a salt thereof, a solvate thereof, or a combination thereof;
human MDA-MB231 breast cancer cells;
DMSO; and
at least one chemotherapeutic agent selected from the group consisting of doxorubicin, imatinib, and sorafenib;
wherein R 1 and R 2 are alkyl groups independently selected from the group consisting of methyl, ethyl and isopropyl;
R 3 , R 4 , and R 5 are independently selected from the group consisting of an optionally substituted C 1 -C 3 alkyl, an optionally substituted C 3 -C 5 cycloalkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted arylolefin, an optionally substituted vinyl; and
with the proviso that R 1 , R 2 , R 3 , R 4 , and R 5 are not each an ethyl.

2. The cancer cell composition of claim 1 , wherein R 1 and R 2 are the same, and R 3 , R 4 , and R 5 are the same optionally substituted C 1 -C 3 alkyl group.

3. The cancer cell composition of claim 2 , wherein R 1 and R 2 are methyls, and R 3 , R 4 , and R 5 are selected from the group consisting of methyl, ethyl, and isopropyl.

4. The cancer cell composition of claim 2 , wherein R 1 and R 2 are ethyls, and R 3 , R 4 , and R 5 are methyls.

5. The cancer cell composition of claim 1 , wherein R 1 and R 2 are methyls and R 3 , R 4 , and R 5 are ethyls.

6. The cancer cell composition of claim 1 , wherein R 1 , R 2 , R 3 , R 4 , and R 5 are each a methyl group.

Assignees

• Univ King Fahd Pet & Minerals
• Univ King Saud

Inventors

• Al-Jaroudi Said S
• Alhoshani Ali
• Altaf Muhammad
• Isab Anvarhusein Abdulkadir

Classifications

• G01N33/57515

  of the breast · CPC title

• C12Q2600/156

  Polymorphic or mutational markers · CPC title

• A61K9/0053

  Mouth and digestive tract, i.e. intraoral and peroral administration · CPC title

• G01N2800/52

  Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title

• A61N1/30

  Apparatus for iontophoresis, {i.e. transfer of media in ionic state by an electromotoric force into the body}, or cataphoresis · CPC title