Nitroxyl progenitor compounds and methods of use

US10273202B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-10273202-B2
Application numberUS-201414492741-A
CountryUS
Kind codeB2
Filing dateSep 22, 2014
Priority dateJan 30, 2004
Publication dateApr 30, 2019
Grant dateApr 30, 2019

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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Abstract

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Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.

First claim

Opening claim text (preview).

What is claimed: 1. A compound of formula (I), or a pharmaceutically acceptable salt thereof: wherein: R 1 and R 2 , together with the nitrogen to which they are both attached, form a heteroaryl ring, wherein the heteroaryl ring is pyrrolyl or indolyl; wherein the heteroaryl ring is optionally substituted with from 1-4 groups selected from the group consisting of halo, COOH, NO 2 and ═O; m is 0; and n is 0. 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1 and R 2 , together with the nitrogen to which they are both attached, form a heteroaryl ring, wherein the heteroaryl ring is substituted with from 1-4 groups selected from the group consisting of halo, COOH, NO 2 and ═O. 3. A compound selected from the group consisting of: 4. A pharmaceutical composition comprising a compound of Formula (I) in claim 1 and a pharmaceutically acceptable carrier.

Assignees

Inventors

Classifications

  • C07C291/08Primary

    Azoxy compounds · CPC title

  • Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

  • Antihypertensives · CPC title

  • for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

  • Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

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What does patent US10273202B2 cover?
Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.
Who is the assignee on this patent?
Toscano John P, Pavlos Christopher M, Boppana Preeya Kapur, and 1 more
What technology area does this patent fall under?
Primary CPC classification C07C291/08. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Apr 30 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).