Methods for the administration of iloperidone

Patent metadata

Field	Value
Publication number	US-10272076-B2
Application number	US-201715835872-A
Country	US
Kind code	B2
Filing date	Dec 8, 2017
Priority date	Sep 30, 2004
Publication date	Apr 30, 2019
Grant date	Apr 30, 2019

Abstract

The present invention relates to methods for the identification of genetic polymorphisms that may be associated with a risk for QT prolongation after treatment with iloperidone and related methods of administering iloperidone to patients with such polymorphisms.

First claim

What is claimed is:

1. A method for treating a patient suffering from at least one of: schizophrenia, schizoaffective disorder, depression, bipolar mania/depression, cardiac arrhythmia, Tourette's Syndrome, a psychotic disorder, a delusional disorder, or schizophreniform disorder, with an active pharmaceutical ingredient including at least one of: iloperidone, a pharmaceutically acceptable salt of iloperidone, an active metabolite of iloperidone that is P88, or a pharmaceutically acceptable salt of P88, comprising the steps of:
determining the patient's CYP2D6 genotype; and
administering to the patient an effective amount of the active pharmaceutical ingredient, whereby the amount of the active pharmaceutical ingredient is determined based on the patient's CYP2D6 genotype.

2. The method of claim 1 , wherein the amount of the active pharmaceutical ingredient is decreased if the patient's CYP2D6 genotype indicates decreased enzymatic activity of the CYP2D6 enzyme relative to the wild type.

3. The method of claim 1 , wherein the amount of the active pharmaceutical ingredient is decreased if the patient's CYP2D6G1846A genotype is AA or GA.

4. The method of claim 1 , wherein the amount of the active pharmaceutical ingredient is decreased if the patient's CYP2D6C100T genotype is TT or CT.

5. The method of claim 1 , wherein the patient is suffering from schizophrenia.

6. The method of claim 5 , wherein the patient is at risk for a prolonged QT interval.

7. A method for treating a patient who is a CYP2D6 poor metabolizer and who suffers from at least one of: schizophrenia, schizoaffective disorder, depression, bipolar manialdepression, cardiac arrhythmia, Tourette's Syndrome, a psychotic disorder, a delusional disorder, or schizophreniform disorder, with a pharmaceutically active ingredient including at least one of:
iloperidone, a pharmaceutically acceptable salt of iloperidone, an active metabolite of iloperidone that is P88, or a pharmaceutically acceptable salt of P88,
wherein the patient is administered a lower dosage of the pharmaceutically active ingredient than would be given to an individual who is not a CYP2D6 poor metabolizer.

8. The method of claim 7 , wherein the patient is determined to be a CYP2D6 poor metabolizer based on at least one of the patient's genotype, the patient's phenotype, and the fact that the patient is being treated with an agent that reduces CYP2D6 activity.

9. The method of claim 8 , wherein the patient's genotype includes at least one CYP2D6 allele selected from a group consisting of 2549 A deletion, 1846 G>A, 1707 T deletion, 2935 A>C, 1758 G>T, 2613-2615 AGA deletion, 1023 C>T, 2850 C>T, 4180G>C, 1659 G>A, 1661 G>C, 2850 C>T, 3183 G>A, −1584 C, −1235 A>G, −740C>T, and −678 G>A.

10. The method of claim 8 , wherein the patient's genotype includes at least one deletion of the CYP2D6 gene.

11. The method of claim 8 , wherein the patient's genotype includes a CYP2D7 gene conversion in intron 1.

12. The method of claim 7 , wherein the patient is suffering from of schizophrenia.

13. A method of treating a patient suffering from at least one of: schizophrenia, schizoaffective disorder, depression, bipolar mania/depression, cardiac arrhythmia, Tourette's Syndrome, a psychotic disorder, a delusional disorder, or schizophreniform disorder, with a pharmaceutically active ingredient including at least one of: iloperidone, a pharmaceutically acceptable salt of iloperidone, an active metabolite of iloperidone that is P88, or a pharmaceutically acceptable salt of P88 comprising the steps of:
determining whether the patient is being administered a CYP2D6 inhibitor; and
reducing the dosage of the pharmaceutically active ingredient if the patient is being administered a CYP2D6 inhibitor.

14. The method of claim 13 , wherein the CYP2D6 inhibitor includes at least one of paroxetine, dolasetron, venlafaxin, and fluoxetine.

15. The method of claim 13 , wherein the patient is suffering from schizophrenia.

16. The method of claim 1 , wherein the active pharmaceutical ingredient is iloperidone or a pharmaceutically acceptable salt of iloperidone.

17. The method of claim 1 , wherein the active pharmaceutical ingredient is P88 or a pharmaceutically acceptable salt of P88.

18. The method of claim 7 , wherein the pharmaceutically active ingredient is iloperidone or a pharmaceutically acceptable salt of iloperidone.

19. The method of claim 7 , wherein the pharmaceutically active ingredient is P88 or a pharmaceutically acceptable salt of P88.

20. The method of claim 13 , wherein the pharmaceutically active ingredient is iloperidone or a pharmaceutically acceptable salt of iloperidone.

Assignees

• Vanda Pharmaceuticals Inc

Inventors

• Wolfgang Curt D
• Polymeropoulos Mihael H

Classifications

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• C12Q2600/172

  Haplotypes · CPC title

• A61P25/24

  Antidepressants · CPC title

• A61P25/18

  Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title