Biodegradable magnesium alloys, methods of manufacture thereof and articles comprising the same

Patent metadata

Field	Value
Publication number	US-10266922-B2
Application number	US-201414901409-A
Country	US
Kind code	B2
Filing date	Jul 3, 2014
Priority date	Jul 3, 2013
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

Disclosed herein is an article comprising a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the non-second metallic derivative and the third non-metallic derivative are all chemically different from one another.

First claim

What is claimed is:

1. An article comprising:
a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and
a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

2. The article of claim 1 , where the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of magnesium, calcium, strontium, or a combination thereof; while an inner layer comprises an oxide of scandium, gadolium, cerium, neodymium, dysporium, or a combination thereof.

3. The article of claim 1 , where the article is an implant in the body of a living being.

4. The article of claim 1 , where the protective layer has a thickness of 0.1 nanometers to 500 nanometers.

5. The article of claim 1 , where the base metal is present in an amount of 70 to 98 wt %, the second element is present in an amount of 0.1 to 24.6 wt %, and the third element is present in an amount of 0.1 to 11.4 wt %, based on the total weight of the metal alloy.

6. The article of claim 1 , wherein the base metal is magnesium.

7. The article of claim 1 , wherein the base metal is calcium.

8. The article of claim 1 , wherein the base metal is strontium.

9. The article of claim 1 , wherein the base metal is zinc.

10. The article of claim 1 , wherein the base metal is magnesium, the second element is scandium, and the third element is cerium.

11. An article comprising:
a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof; and
a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another.

12. The article of claim 11 , where the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of calcium, strontium, or a combination thereof; while an inner layer comprises an oxide of scandium, yttrium, gadolium, cerium, neodymium, dysporium, or a combination thereof.

13. The article of claim 11 , wherein the second element is yttrium and the third element is scandium.

14. The article of claim 11 , wherein the second element is yttrium and the third element is selected from gadolium, cerium, neodymium, dysporium, or a combination thereof.

15. The article of claim 11 , wherein the second element is scandium and the third element is selected from gadolium, cerium, neodymium, dysporium, or a combination thereof.

16. An article comprising:
a metal alloy; where the metal alloy comprises a base metal, a second element and a third element; where the base metal is magnesium, calcium, strontium, zinc, or a combination thereof; where the second element is chemically different from the third element; and where the second element and the third element are gadolium, cerium, neodymium, dysporium, or a combination thereof;
a protective layer disposed upon the metal alloy and is reactively bonded to the metal alloy; where the protective layer comprises a base non-metallic derivative, a second non-metallic derivative and a third non-metallic derivative of metals present in the metal alloy; and where the base non-metallic derivative, the second non-metallic derivative and the third non-metallic derivative are all chemically different from one another; and
wherein the protective layer comprises a plurality of layers; with an outermost layer comprising an oxide of magnesium, calcium, strontium, or a combination thereof; while an inner layer comprises an oxide of gadolium, cerium, neodymium, dysporium, or a combination thereof.

17. The article of claim 16 , wherein the outermost layer is an oxide of magnesium.

18. The article of claim 16 , wherein the outermost layer is an oxide of calcium.

19. The article of claim 16 , wherein the outermost layer is an oxide of strontium.

20. The article of claim 16 , wherein the outermost layer is an oxide of zinc.

Assignees

• Univ Florida

Inventors

• Manuel Michele Viola
• Allen Josephine
• Ball Jordan P
• Brar Harpreet Singh
• Berglund Ida Svensson

Classifications

• C22C1/0408

  Light metal alloys · CPC title

• C22C23/00 Primary

  Alloys based on magnesium · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• C22C23/06

  with a rare earth metal as the next major constituent · CPC title

• A61L27/047

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title