Modular biocompatible materials for medical devices and uses thereof

Patent metadata

Field	Value
Publication number	US-10266408-B2
Application number	US-201514597832-A
Country	US
Kind code	B2
Filing date	Jan 15, 2015
Priority date	Dec 28, 2009
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.

First claim

What is claimed is:

1. A method of forming a metal-organic compound containing polymer matrix, the method comprising:
exposing a polymer in the presence of an organic solvent to a three-dimensional metal-organic framework to form a metal-organic compound containing polymer matrix; and
drying the metal-organic compound containing polymer matrix, wherein the metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework, and wherein the three-dimensional metal-organic framework includes a polydentate organic linker having the formula

wherein X 1 , X 2 and X 3 are nitrogen-containing heteroaromatic compounds selected from the group consisting of triazoyl and tetrazoyl;
R is an aromatic compound selected from the group consisting of benzene and naphthalene, wherein the benzene and naphthalene are substituted or unsubstituted; and wherein the three-dimensional metal-organic framework includes a metal selected from the group consisting of copper, zinc, iron, cobalt, manganese, vanadium, molybdenum, tungsten, chromium, nickel, aluminum and mixtures thereof; and
a nitric-oxide releasing functional group is covalently bound to the polydentate organic linker.

2. The method of claim 1 wherein X 1 , X 2 and X 3 are triazolyls.

3. The method of claim 1 wherein X 1 , X 2 and X 3 are tetrazoyls.

4. The method of claim 1 , wherein the metal-organic framework has a porous structure comprising pores having an average size of about 5 Å to about 500 Å in diameter.

5. The method of claim 1 , wherein the nitric oxide-releasing compound comprises a functional group selected from the group consisting of S-nitrosothiol, diazeniumdiolate, nitrate, nitrite, nitroso, and nitrosyl.

6. The method of claim 1 , wherein the polymer is selected from the group consisting of poly(ε-caprolactone) and polyglycolide and mixtures and copolymers thereof.

7. The method of claim 1 , wherein the polymer is selected from the group consisting of polyurethane (PU), polyesters, polyethers, silicones, silicates, poly(vinyl chloride) (PVC), acrylates, methacrylates, dextran, synthetic rubber (cis-polyisoprene), polyvinyl acetate, polyoxybenzylmethylenglycolanhydride (BAKELITE®), polychloroprene (NEOPRENE®), nylon, polystyrene, polyethylene, polypropylene, polyacrylonitrile, polyvinyl butyral (PVB), poly(vinylidene chloride), fluorinated polymers, polytetrafluoroethylene (PTFE), poly(ε-caprolactone), polyglycolide and mixtures and copolymers thereof.

8. The method of claim 1 , wherein the metal is copper.

9. The method of claim 8 , wherein X 1 , X 2 and X 3 are tetrazoyls.

10. The method of claim 9 , wherein R is benzene.

11. The method of claim 9 , wherein R is naphthalene.

12. The method of claim 8 , wherein X 1 , X 2 and X 3 are triazolyls.

13. The method of claim 12 , wherein R is benzene.

14. The method of claim 12 , wherein R is naphthalene.

15. The method of claim 1 , wherein the three-dimensional metal-organic framework is Cu 3 (1,3,5-benzenetricarboxylic acid) 2 .

16. The method of claim 1 , wherein the three-dimensional metal-organic framework is Cu(1,3,5-benzenetristetrazolate).

Assignees

• Univ Colorado State Res Found

Inventors

• Reynolds Melissa M
• Reynolds Benjamin P

Classifications

• A61P7/02

  Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title