Apparatus for measurement of spinning forces relating to molecules

Patent metadata

Field	Value
Publication number	US-10265705-B2
Application number	US-201615141692-A
Country	US
Kind code	B2
Filing date	Apr 28, 2016
Priority date	Dec 2, 2008
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

An apparatus for measuring a characteristic of a sample includes a sample measurement apparatus ( 1404 ), which includes a light source ( 1406 ) configured to illuminate the sample; and a detector ( 1412 ) configured to receive light from the sample. The sample measurement apparatus is sized and dimensioned to fit within a centrifuge receptacle, the centrifuge receptacle ( 1416 ) coupled to a spindle configured to rotate the centrifuge receptacle to apply a force to the sample.

First claim

What is claimed is:

1. An apparatus for measuring a characteristic of a sample, the apparatus comprising:
a sample measurement apparatus, comprising:
a light source configured to illuminate the sample; and
a detector configured to receive light from the light source, the light source and the detector being physically arranged such that light from the light source is received by the detector after illuminating the sample,

the sample measurement apparatus being configured to retain a sample chamber having the sample to prevent relative movement between the sample chamber and the detector during centrifugation of the sample measurement apparatus by a centrifuge,
wherein the sample measurement apparatus is configured to be removably received within a sample holding portion of the centrifuge, the sample measurement apparatus being distinct from the sample holding portion of the centrifuge.

2. The apparatus of claim 1 , wherein the sample measurement apparatus further comprises a lens configured to receive light from the sample, and wherein the detector is configured to receive light passing through_the lens.

3. The apparatus of claim 2 , wherein the lens includes an aspheric lens.

4. The apparatus of claim 2 , wherein the sample measurement apparatus includes only one lens.

5. The apparatus of claim 1 , further comprising a centrifuge receptacle configured to receive the sample measurement apparatus.

6. The apparatus of claim 5 , further comprising a base disposed within the centrifuge receptacle and configured to receive the sample measurement apparatus.

7. The apparatus of claim 5 , wherein the centrifuge receptacle includes at least one of a centrifuge tube, a swing bucket, and a rotor.

8. The apparatus of claim 5 , wherein the centrifuge receptacle is a centrifuge tube having a volume of less than or equal to about 50 mL.

9. The apparatus of claim 2 , wherein the sample measurement apparatus further includes a lens tube, wherein the light source, the lens, and the detector are disposed within the lens tube.

10. The apparatus of claim 5 , further comprising a battery coupled to the centrifuge receptacle and electrically connected to the light source and the detector.

11. The apparatus of claim 10 , wherein the battery is disposed within the centrifuge receptacle.

12. The apparatus of claim 5 , further comprising a recording device coupled to the centrifuge receptacle, the recording device configured to record a signal received from the detector.

13. The apparatus of claim 12 , wherein the recording device is disposed within the centrifuge receptacle.

14. The apparatus of claim 1 , further comprising a wireless communications module configured to wirelessly transmit a signal received from the detector.

15. The apparatus of claim 1 , further comprising a computing device electrically connected to the detector.

16. The apparatus of claim 15 , wherein the detector is electrically connected to the computing device via a rotary joint.

17. The apparatus of claim 5 , further comprising a computing device external to the centrifuge receptacle.

18. The apparatus of claim 17 , wherein the detector is optically connected to the computing device via a fiber optic rotary joint.

19. The apparatus of claim 5 , wherein an optical axis of the sample measurement apparatus is substantially perpendicular to an axis of rotation of the centrifuge receptacle.

20. The apparatus of claim 1 , wherein the sample measurement apparatus further comprises a first mirror configured to reflect light from the light source toward the detector.

21. The apparatus of claim 20 , further comprising a second mirror that reflects light from the light source toward the first mirror.

22. The apparatus of claim 20 , wherein the sample measurement apparatus comprises a U-shaped assembly having a first leg and a second leg, the light source being positioned at the first leg and the detector being positioned at the second leg.

23. The apparatus of claim 20 , further comprising a centrifuge receptacle configured to receive the sample measurement apparatus.

Assignees

• Harvard College

Inventors

• Wong Wesley Philip
• Halvorsen Kenneth Anders

Classifications

• G06T7/20

  Analysis of motion (motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51) · CPC title

• G01N2015/0065

  Physics · mapped topic

• G01N11/00

  Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties · CPC title

• G01N33/54313 Primary

  the carrier being characterised by its particulate form · CPC title

• G01N15/1463

  Physics · mapped topic