Blood filter and method of manufacturing the same

Patent metadata

Field	Value
Publication number	US-10265456-B2
Application number	US-201515540817-A
Country	US
Kind code	B2
Filing date	Dec 28, 2015
Priority date	Dec 30, 2014
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

Disclosed are a blood filter which exhibits excellent leukocyte elimination performance as well as significantly improved blood throughput per unit time and erythrocyte recovery rate and a method of manufacturing the same. The blood filter of the present invention includes a pre-treatment filter which is a laminate of first non-woven fabrics having a mean fiber diameter of 5 to 30 μm and a mean pore size of 10 to 30 μm, and a main filter which is a laminate of second non-woven fabrics having a mean fiber diameter of 1 to 5 μm, a mean pore size of 5 to 10 μm and a mean pore size distribution rate of 30% or more. A filling density of the pre-treatment filter and a filling density of the main filter, with respect to a target blood throughput of the blood filter, are 0.1 g/100 ml to 1 g/100 ml and 1 g/100 ml to 3 g/100 ml, respectively.

First claim

The invention claimed is:

1. A method of manufacturing a blood filter, the method comprising:
producing first melt-blown non-woven fabrics having a mean fiber diameter of 5 to 30 μm and a mean pore size of 10 to 30 μm;
laminating the first melt-blown non-woven fabrics to produce a pre-treatment filter;
producing second melt-blown non-woven fabrics having a mean fiber diameter of 1 to 5 μm, a mean pore size of 5 to 10 μm and a mean pore size distribution rate of 30% or more;
laminating the second melt-blown non-woven fabrics to produce a main filter; and
mounting the pre-treatment filter and the main filter in a case,
wherein the first melt-blown non-woven fabrics are laminated such that a filling density of the pre-treatment filter with respect to a target blood throughput of the blood filter is 0.1 g/100 ml to 1 g/100 ml, and
the second melt-blown non-woven fabrics are laminated such that a filling density of the main filter with respect to the target blood throughput of the blood filter is 1 g/100 ml to 3 g/100 ml.

2. The method according to claim 1 , wherein the producing of the first melt-blown non-woven fabrics comprises:
melting polyethylene terephthalate or polybutylene terephthalate to prepare a first dope;
spinning the first dope through a first die to form first fibers; and
collecting the first fibers on a first collector,
wherein a distance from the first die to the first collector is 200 mm or more.

3. The method according to claim 2 , wherein the producing of the second melt-blown non-woven fabrics comprises:
melting polyethylene terephthalate or polybutylene terephthalate to prepare a second dope;
spinning the second dope through a second die to form second fibers; and
collecting the second fibers on a second collector,
wherein the spinning of the second dope comprises:
discharging the second dope through a nozzle of the second die; and
spraying air to the second dope before discharging through the nozzle,
wherein a distance from the second die to the second collector is 60 mm or less, and an angle between the nozzle and the air is 60° or less.

Assignees

• Kolon Inc

Inventors

• Lee Min Ho
• Kim Jin Il

Classifications

• B01D2239/0421

  Rendering the filter material hydrophilic · CPC title

• B01D39/1623

  of synthetic origin · CPC title

• B01D2239/0622

  Melt-blown · CPC title

• A61M1/3403 Primary

  Regulation parameters · CPC title

• B01D2239/1216

  Pore size · CPC title