Synergistic antibacterial effects of magnolia bark extract and L-arginine, N-α-lauroyl ethyl ester on plaque biofilm

Patent metadata

Field	Value
Publication number	US-10265367-B2
Application number	US-201615757214-A
Country	US
Kind code	B2
Filing date	Sep 12, 2016
Priority date	Sep 11, 2015
Publication date	Apr 23, 2019
Grant date	Apr 23, 2019

Abstract

The present disclosure relates generally to oral compositions and methods for inhibiting the formation of plaque biofilm by salivary bacteria, and more particularly, to oral compositions comprising a combination of magnolia bark extract (MBE) and L-arginine, N α -lauroyl ethyl ester (LAE). The oral compositions are useful for improving oral health, including inhibiting the formation of plaque biofilm by salivary bacteria and reducing plaque adherence to teeth.

First claim

What is claimed is:

1. An oral composition for inhibiting the formation of plaque biofilm by salivary bacteria in an oral cavity of a consumer, the composition comprising magnolia bark extract (MBE) and L-arginine, N α -lauroyl-ethyl ester (LAE), wherein the oral composition comprises the MBE and LAE in amounts that provide a synergistic inhibition of the formation of plaque biofilm in the oral cavity.

2. The oral composition of claim 1 , wherein the weight ratio of MBE to LAE is from about 16:1 to about 4:1.

3. The oral composition of claim 1 , wherein the oral composition comprises from about 1 to about 20 mg of MBE.

4. The oral composition of claim 1 , wherein the oral composition comprises from about 1 to about 10 mg of MBE.

5. The oral composition of claim 1 , wherein the oral composition comprises from about 1 to about 20 mg of LAE.

6. The oral composition of claim 1 , wherein the oral composition is selected from the group consisting of a chewing gum, a confection, a mint, a tablet, a bead, and a lozenge.

7. The oral composition of claim 1 , wherein the oral composition is a chewing gum, and the synergistic inhibition of the formation of plaque biofilm in the oral cavity occurs after a chewing time of at least 10 minutes.

8. The oral composition of claim 1 , wherein the oral composition reduces the adherence of plaque to teeth.

9. A coated oral composition for inhibiting the formation of plaque biofilm by salivary bacteria in an oral cavity of a consumer, the coated oral composition comprising MBE and LAE in a weight ratio from about 16:1 to about 4:1 that provide a synergistic inhibition of the formation of plaque biofilm in the oral cavity.

10. The coated oral composition of claim 9 , wherein the MBE comprises from about 1% to about 2% by weight of the coating.

11. The coated oral composition of claim 9 , wherein the LAE comprises from about 1% to about 2% by weight of the coating.

12. The coated oral composition of claim 9 , wherein the coated oral composition is selected from the group consisting of a chewing gum, a confection, a mint, a tablet, a bead, and a lozenge.

13. The coated oral composition of claim 9 , wherein the coated oral composition is a chewing gum and the synergistic inhibition of the formation of plaque biofilm in the oral cavity occurs after a chewing time of at least 10 minutes.

14. A method of making a coated oral composition, the method comprising:
pretreating MBE and LAE to form a preblend mixture;
adding the preblend mixture to a coating syrup; and,
applying the coating syrup to an oral composition to produce the coated oral composition,
wherein the coated oral composition comprises MBE and LAE in amounts that provide a synergistic inhibition of the formation of plaque biofilm by salivary bacteria in an oral cavity of a consumer.

15. The method of claim 14 , wherein the oral composition is selected from the group consisting of a chewing gum, a confection, a mint, a tablet, a bead, and a lozenge.

16. The method of claim 14 , wherein the MBE and LAE are pretreated by blending the MBE and LAE with one or more organoleptic components.

17. The method of claim 14 , wherein the MBE and LAE are pretreated by sieving the MBE and LAE.

18. The method of claim 14 , wherein the weight ratio of MBE to LAE in the preblend mixture is from about 16:1 to about 8:1.

19. The method of claim 14 , wherein the MBE comprises from about 1% to about 2% by weight of the coating.

20. The method of claim 14 , wherein the LAE comprises from about 1% to about 2% by weight of the coating.

21. The method of claim 14 , wherein the coated oral composition is a coated chewing gum.

22. The method of claim 14 , wherein the MBE and LAE are pretreated by blending the MBE and LAE with a powdered gum base.

23. The method of claim 14 , wherein the MBE and LAE are pretreated by pre-dissolving the MBE and LAE in a flavoring agent, glycerol, MCT oil, or combinations thereof.

24. The method of claim 14 , wherein the weight ratio of MBE to LAE in the preblend mixture is from about 16:1 to about 4:1.

25. The method of claim 14 , wherein the weight ratio of MBE to LAE in the preblend mixture is from about 8:1 to about 4:1.

26. The method of claim 14 , wherein the weight ratio of MBE to LAE in the preblend mixture is from about 16:1 to about 8:1.

Assignees

• Wrigley W M Jun Co

Inventors

• Dodds Michael W
• Tian Minmin
• Inui Taichi
• Ramirez Lilian
• Aspiras Marcelo B

Classifications

• A61K8/9789

  Magnoliopsida [dicotyledons] · CPC title

• A23G4/12

  containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins (containing dairy products A23G4/16) · CPC title

• A23G3/44

  containing peptides or proteins (containing dairy products A23G3/46) · CPC title

• A23G4/068

  containing plants or parts thereof, e.g. fruits, seeds, extracts (containing gums A23G4/10) · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title