Labeled evans blue dye derivative for in vivo serum albumin labeling

Patent metadata

Field	Value
Publication number	US-10258701-B2
Application number	US-201715587948-A
Country	US
Kind code	B2
Filing date	May 5, 2017
Priority date	Mar 31, 2015
Publication date	Apr 16, 2019
Grant date	Apr 16, 2019

Abstract

Disclosed is a compound of formula (I):

wherein L, R 1 -R 5 , A, B, M, and n are as defined in the specification, as well as a method of preparing the compound. Also disclosed are a method of blood-pool imaging in a mammal and a method of imaging a lymph node in a mammal, comprising use of the compound.

First claim

The invention claimed is:

1. A method of imaging a lymph node in a mammal, consisting of administering to the mammal a compound of formula (I):

Wherein M is selected from 18 F-AlF, 60 Cu, 61 Cu, 62 Cu, 64 Cu, 67 Cu, 68 Ga, 86 Y, 89 Zr, 111 In, 99m Tc, 186 Re, 188 Re, Gd 3+ , and Mn 2+ , and PET imaging the mammal, and optionally, coadministering to the mammal Evans blue dye, and visually imaging the mammal.

2. The method of claim 1 , wherein the compound of formula (I) is:

3. The method of claim 1 , wherein M is 18 F-AlF, 64 Cu, or 68 Ga.

4. The method of claim 3 , wherein the compound of formula (I) is:

5. The method of claim 1 , wherein the lymph node is a sentinel lymph node.

Assignees

• Us Health

Inventors

• Chen Xiaoyuan
• Lang Lixin
• Niu Gang

Classifications

• C07B59/004

  Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium · CPC title

• C09B29/30

  Amino naphtholsulfonic acid · CPC title

• A61K51/0482 Primary

  chelates from cyclic ligands, e.g. DOTA · CPC title

• C09B45/00

  Complex metal compounds of azo dyes · CPC title