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Compositions and methods of treating root avulsion injury
US10258672B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10258672-B2 |
| Application number | US-201615274236-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 23, 2016 |
| Priority date | Oct 9, 2014 |
| Publication date | Apr 16, 2019 |
| Grant date | Apr 16, 2019 |
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- Title
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- Abstract
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Abstract
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A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ.
First claim
Opening claim text (preview).
Having described the invention, we claim: 1. A method of treating root avulsion injury in a subject in need thereof, the method comprising: administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ, wherein the therapeutic agent comprises a therapeutic peptide, the therapeutic peptide including an amino acid sequence selected from the group consisting of SEQ ID NO: 32 and SEQ ID NO: 63. 2. The method of claim 1 , the therapeutic agent comprising a therapeutic peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO: 32 and SEQ ID NO: 63. 3. The method of claim 1 , wherein the therapeutic agent includes a transport moiety that is linked to the therapeutic peptide and facilitates uptake of the therapeutic peptide by a nerve cell being treated. 4. The method of claim 3 , wherein the transport moiety is an HIV Tat transport moiety. 5. The method of claim 3 , wherein the therapeutic agent is administered systemically to the subject being treated. 6. The method of claim 1 , further comprising connecting an avulsed end in a peripheral nerve to a portion of the central nervous system. 7. The method of claim 1 , wherein the therapeutic agent is administered at an amount effective to increase survival rate of injured motoneurons, enhance regrowth across inhibitory central nervous system scar into re-implanted spinal roots, regenerate axons, decrease muscle atrophy, and/or promote motor functional recovery.
Assignees
Inventors
Classifications
Protein-tyrosine-phosphatase (3.1.3.48) · CPC title
Cytokines; Lymphokines; Interferons · CPC title
Enzyme inhibitors (protease inhibitors A61K38/55) · CPC title
- A61K38/465Primary
acting on ester bonds (3.1), e.g. lipases, ribonucleases · CPC title
Antigen-pulsed cells, e.g. T-cells · CPC title
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Frequently asked questions
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- What does patent US10258672B2 cover?
- A method of treating root avulsion injury in a subject in need thereof includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ.
- Who is the assignee on this patent?
- Univ Case Western Reserve, Univ Hong Kong
- What technology area does this patent fall under?
- Primary CPC classification A61K38/465. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Apr 16 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).