Oral care compositions and methods of using the compositions

Patent metadata

Field	Value
Publication number	US-10258551-B2
Application number	US-201715630246-A
Country	US
Kind code	B2
Filing date	Jun 22, 2017
Priority date	Jun 24, 2016
Publication date	Apr 16, 2019
Grant date	Apr 16, 2019

Abstract

An oral care composition comprising zinc phosphate and stannous fluoride.

First claim

We claim:

1. An oral care composition, comprising:
an orally acceptable carrier;
zinc phosphate; and
stannous fluoride,
wherein the amount of zinc phosphate is from 0.05 to 5% by weight, relative to the weight of the oral care composition and wherein the amount of the water is about 12% by weight or more, relative to the weight of the oral care composition.

2. The oral care composition of claim 1 , wherein the zinc phosphate is a preformed salt of zinc phosphate.

3. The oral care composition of claim 1 , wherein zinc phosphate is present in an amount sufficient so that the stannous fluoride dissociates to provide a therapeutically effective amount of stannous ions in aqueous solution.

4. The oral care composition of claim 1 , wherein the amount of the stannous fluoride is from 0.05% to 5% by weight, relative to the weight of the oral care composition.

5. The oral care composition of claim 1 , wherein the oral care composition further comprises an abrasive.

6. The oral care composition of claim 1 , further comprising one or more humectants and/or one or more surfactants.

7. The oral care composition of claim 1 , further comprising an effective amount of one or more alkali phosphate salts.

8. The oral care composition of claim 1 , further comprising a whitening agent.

9. The oral care composition of claim 1 , further comprising one or more sources of zinc ions in addition to the zinc phosphate.

10. The oral care composition of claim 1 , wherein the oral care composition is a dentifrice, powder, cream, strip or gum.

11. An oral care composition according to claim 1 , which comprises:
from 0.5 to 3% by weight zinc phosphate;
from 0.05 to 11% by weight stannous fluoride;
from 1 to 8% by weight alkali phosphate salts selected from sodium phosphate dibasic, potassium phosphate dibasic, dicalcium phosphate dihydrate, tetrasodium pyrophosphate, tetrapotassium pyrophosphate, calcium pyrophosphate, sodium tripolyphosphate, and mixtures of any two or more of these, relative to the weight of the oral care composition; and
a silica abrasive.

12. The oral care composition of claim 1 , wherein the oral care composition is a gel.

13. The oral care composition of claim 1 , wherein the pH of the composition is less than 7.

14. A method of treating or reducing dental enamel erosion comprising administering a composition according to claim 1 to the oral cavity of a subject in need thereof.

15. The method of claim 14 , wherein at least one tooth is remineralized after administration of said composition.

Assignees

• Colgate Palmolive Co

Inventors

• Rege Aarti
• Sullivan Richard
• Suriano David
• Dogu Nihal
• Colligan Mary
• Fisher Steven
• Morgan Andre

Classifications

• A61K8/24

  Phosphorous; Compounds thereof · CPC title

• A61K8/21 Primary

  Fluorides; Derivatives thereof · CPC title

• A61K8/36

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• A61K8/27 Primary

  Zinc; Compounds thereof · CPC title

• A61K2800/51

  Chelating agents · CPC title