Apparatus for determining a fractional flow reserve value

Patent metadata

Field	Value
Publication number	US-10258303-B2
Application number	US-201515317158-A
Country	US
Kind code	B2
Filing date	Jun 24, 2015
Priority date	Jun 30, 2014
Publication date	Apr 16, 2019
Grant date	Apr 16, 2019

Abstract

The invention relates to an apparatus for determining a fractional flow reserve (FFR) value of the coronary artery system of a living being (3). A fractional flow reserve value determination unit (13) determines the FFR value by using an FFR value determination algorithm that is adapted to determine the FFR value based on a boundary condition and a provided representation of the coronary artery system, wherein the boundary condition is specific for the living being and determined by a boundary condition determination unit (12). Since the boundary condition determination unit determines a boundary condition, which is specific for the living being, and since the fractional flow reserve value determination unit not only uses the provided representation of the coronary artery system, but also the living being specific boundary condition for determining the FFR value, the accuracy of the FFR value, which is non-invasively determined, can be improved.

First claim

The invention claimed is:

1. An apparatus for determining a fractional flow reserve value of the coronary artery system of a living being, the apparatus comprising:
a representation providing unit for providing a representation of the coronary artery system;
a projection data providing unit for providing projection data comprising:
a radiation source configured to generate radiation during a contrast enhanced scan of an aorta of a living being,
a detector configured to generate projection data based on the radiation, and
a region between the radiation source and the detector with the living being disposed therein,
wherein the detector has several rows of detection elements used for generating the projection data, and
wherein the radiation source is adapted such that not all rows of the detection elements are irradiated, but only one row is irradiated by a single fan beam or at least one row is irradiated by several fan beams;

a boundary condition determination unit for determining a boundary condition which is specific for the living being based on the provided projection data; and
a fractional flow reserve value determination unit for determining the fractional flow reserve value by using a fractional flow reserve value determination algorithm that is adapted to determine the fractional flow reserve value based on the boundary condition and the provided representation of the coronary artery system.

2. The apparatus as defined in claim 1 , wherein the projection data providing unit is adapted to provide fan beam projection data having been generated by the detector over time based on radiation, which is generated by the radiation source and which has traversed the aorta at different locations, while a contrast agent has flown through the aorta from one of the different locations to another of the different locations, wherein the boundary condition determination unit is adapted to determine the boundary condition based on the provided projection data.

3. The apparatus as defined in claim 2 , wherein the representation providing unit is adapted to further provide a representation of the aorta showing the aorta between the different locations, wherein the boundary condition determination unit is adapted to determine the boundary condition based on the provided projection data and the representation of the aorta.

4. The apparatus as defined in claim 1 , wherein the boundary condition determination unit is adapted to reconstruct an image showing the coronary artery system and surrounding regions, which surround vessels of the coronary artery system, over time based on the provided projection data and to determine an amount of blood leaving the coronary artery system based on the image as the boundary condition.

5. The apparatus as defined in claim 4 , wherein the boundary condition determination unit is adapted to determine the amount of blood leaving the coronary artery system based on image values of image elements showing the surrounding regions.

6. The apparatus as defined in claim 5 , wherein the boundary condition determination unit is adapted to determine a myocardial tissue value being indicative of an uptake of a part of a contrast agent in the myocardial tissue based on the image values of the image elements showing the surrounding regions and to determine the amount of blood leaving the coronary artery system based on the myocardial tissue value.

7. The apparatus as defined in claim 5 , wherein the boundary condition determination unit is adapted to determine which image elements showing the surrounding regions represent side branches of the vessels of the coronary artery system, which are too small for being represented by the provided representation of the coronary artery system, based on the image values of the image elements showing the surrounding regions and to determine the amount of blood leaving the coronary artery system through the side branches based on the determined image elements.

8. The apparatus as defined in claim 1 , wherein the boundary condition determination unit is adapted to determine a flow velocity and/or dimensions of the coronary arteries at the outlets of the coronary artery system as a boundary condition.

9. The apparatus as defined in claim 1 , wherein the apparatus further comprises a property providing unit for providing anatomical and/or physiological properties of the living being, wherein the boundary condition determination unit is adapted to determine the boundary condition based on the provided properties of the living being.

10. The apparatus as defined in claim 9 , wherein the property providing unit is adapted to provide a cross-section area of a vessel of the coronary artery system and/or a myocardial mass and/or a ratio of diameters of a vessel and its branch of the coronary artery system and/or the heart size and/or the ejection fraction of the heart and/or the stroke volume of the heart as the property.

11. The apparatus as defined in claim 1 , wherein the fractional flow reserve value determination unit is adapted to use a fractional flow reserve value determination algorithm that is based on a lumped model describing the flow within the coronary artery system and wherein the boundary condition determination unit is adapted to determine parameters of the lumped model as the boundary condition.

12. A method for determining a fractional flow reserve value of the coronary artery system of a living being, the method comprising:
providing a representation of the coronary artery system by a representation providing unit;
generating a fan beam of radiation with a radiation source during a contrast enhanced scan of a vessel of a subject, wherein the fan beam traverses the vessel in an examination region;
receiving a single fan beam of the generated radiation traversing the vessel with only a single row of a multi-row detector or receiving a plurality of fan beams with a plurality of rows of the multi-row detector;
providing, with the multi-row the detector, projection data based on the received radiation;
determining a boundary condition which is specific for the living being by a boundary condition determination unit based on the provided projection data; and
determining the fractional flow reserve value by using a fractional flow reserve value determination algorithm that is configured to determine the fractional flow reserve value based on a boundary condition and the provided representation of the coronary artery system by a fractional flow reserve value determination unit.

13. A non-transitory computer program for determining a fractional flow reserve value of the coronary artery system of a living being, the computer program comprising program code means for causing an apparatus to carry out the steps of:
providing a representation of the coronary artery system by a representation providing unit;
generating radiation with a radiation source of a projection data providing unit during a contrast enhanced scan of an aorta of a living being;
irradiating a detector of the projection data providing unit with the radiation, wherein the detector has several rows of detection elements used for generating projection data and wherein not all rows of the detection elements are irradiated, but only one row is irradiated by a single fan beam or at least one row is irradiated by several fan beams;
providing projection data generated by the detector of the projection data providing unit based on the radiation,
determining a boundary condition which is specific for the living being by a boundary condition determination unit based on the provided projection data; and
determining the fractional flow reserve value b

Assignees

• Koninklijke Philips Nv

Inventors

• Grass Michael
• Lamash Yechiel
• Goshen Liran
• Schmitt Holger
• Freiman Mordechay Pinchas
• Nickisch Hannes
• Prevrhal Sven

Classifications

• A61B6/5217

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• A61B5/029

  Measuring blood output from the heart, e.g. minute volume · CPC title

• A61B6/4233

  using matrix detectors · CPC title

• A61B6/507 Primary

  for determination of haemodynamic parameters, e.g. perfusion CT · CPC title

• A61B6/481

  involving the use of contrast agents · CPC title