Analyte testing automation system, biological sample check module, and biological sample check method

Patent metadata

Field	Value
Publication number	US-10247743-B2
Application number	US-201415031412-A
Country	US
Kind code	B2
Filing date	Oct 31, 2014
Priority date	Nov 12, 2013
Publication date	Apr 2, 2019
Grant date	Apr 2, 2019

Abstract

The type of blood collection tube ( 1 ) inserted into this system is automatically recognized, a lifting operation for checking the state and volume of analyte is switched on the basis of the automatic recognition result, a mechanical operation parameter based on the blood collection tube type is determined, and the blood collection tube ( 1 ) is grasped and lifted. Then, an image processing threshold is changed on the basis of the automatic recognition result, and image processing is performed using a threshold parameter based on the blood collection tube type to check the state and volume of the analyte. This enables precise automatic checking of the state and/or volume of the analyte for various types of blood collection tubes.

First claim

The invention claimed is:

1. An analyte testing automation system comprising:
a camera configured to capture an image of a container, in which a biological sample is stored, from a side thereof;
a grip member configured to grasp and lift the container;
a database which stores a plurality of different container types that specify a plurality of different lifting operation parameters and a plurality of different threshold parameters;
a controller coupled to the camera and the grip member, and programmed to:
control the camera to capture a first image of the container,
determine a container type of the container from among the different container types stored in the database according to a length, a diameter and a cap color of the container in the first image,
determine a lifting operation parameter and a threshold parameter of the container from the different lifting operation parameters and the different threshold parameters in the database specified by the determined container type,
control the grip member to lift the container to a predetermined height specified by the lifting operation parameter,
capture a second image of the container in a state where the container is lifted to the predetermined height by the grip member,
compare the second image to one or more predetermined color values specified by the threshold parameter, and
determine a state of an analyte in the biological sample in the container from the comparison.

2. The analyte testing automation system according to claim 1 ,
wherein the grip member is further configured to lift the container from a holder,
the controller is further programmed to control the camera to capture the first image while the container is held by the holder, and the first image and the second image are captured by the camera from the side of the container.

3. The analyte testing automation system according to claim 1 ,
wherein the different container types include a transparent container and a white translucent container.

4. The analyte testing automation system according to claim 1 ,
wherein the controller is further programmed to discriminate a position of a liquid interface of the biological sample, a presence of a separating agent or a presence of a label from the second image.

5. The analyte testing automation system according to claim 1 , wherein the determined state is one of a hemolytic state, a chylous state and icteric state.

6. The analyte testing automation system according to claim 1 , wherein a barcode label is attached to the container,
the gripping member is further configured to rotate the container, and
after capturing the first image and before capturing the second image, the controller is further configured to control the grip member to rotate the container until a gap in the barcode label faces the camera.

7. A biological sample check module for checking a biological sample stored in a container, comprising:
a camera configured to capture an image of the container, in which the biological sample is stored, from a side thereof;
a grip member configured to grasp and lift the container; and
a controller programmed to control the camera to:
capture a first image of the container,
determine a container type of the container from a length, a diameter and a cap color of the container in the first image,
determine a lifting operation parameter and a threshold parameter of the container specified by the determined container type,
control the grip member to lift the container to a predetermined height specified by the lifting operation parameter,
capture a second image of the container in a state where the container is lifted to the predetermined height by the grip member,
compare the second image to one or more predetermined color values specified by the threshold parameter, and
determine a state of the biological sample in the container from the comparison.

8. The biological sample check module according to claim 7 , wherein the determined state is one of a hemolytic state, a chylous state and icteric state.

9. The biological sample check module according to claim 7 , wherein a barcode label is attached to the container,
the gripping member is further configured to rotate the container, and
after capturing the first image and before capturing the second image, the controller is further configured to control the grip member to rotate the container until a gap in the barcode label faces the camera.

10. A biological sample check method, comprising:
capturing a first image of a container in which a biological sample is stored from a side thereof;
determining a container type of the container among a plurality of different container types from a length, a diameter and a cap color of the container in the first image;
determining a lifting operation parameter and a threshold parameter of the container specified by the determined container type;
controlling a grip member to lift the container to a predetermined height specified by the lifting operation parameter;
capturing a second image of the container from a side thereof in a state where the container is lifted to the predetermined height by the grip member;
comparing the second image to one or more predetermined color values specified by the threshold parameter, and
determining a state of the biological sample in the container from the comparison.

11. The biological sample check method according to claim 10 ,
wherein the first image is captured while the container is held by a holder and the second image is captured while the grip member lifts the container to the predetermined height from the holder.

12. The biological sample check method according to claim 10 ,
wherein the determined container type is one of a transparent container or a white translucent container.

13. The biological sample check method according to claim 10 , further comprising:
determining a position of a liquid interface of the biological sample, a presence of a separating agent, or a presence of a label from the second image.

14. The biological sample check method according to claim 10 , wherein a barcode label is attached to the container, and
after capturing the first image and before capturing the second image, the grip member rotates the container until a gap in the barcode label faces the camera.

15. The biological sample check method according to claim 10 , wherein the determined state is one of a hemolytic state, a chylous state and icteric state.

Assignees

• Hitachi High Tech Corp

Inventors

• Suzuki Iwao
• SUENARI Tsukasa
• Sasaki Takahiro
• Takahashi Kenichi

Classifications

• G01N2015/055

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