Magnesium-zinc-strontium alloys for medical implants and devices

Patent metadata

Field	Value
Publication number	US-10246763-B2
Application number	US-201313975881-A
Country	US
Kind code	B2
Filing date	Aug 26, 2013
Priority date	Aug 24, 2012
Publication date	Apr 2, 2019
Grant date	Apr 2, 2019

Abstract

A medical implant and/or device, which includes a biodegradable and cytocompatible magnesium-zinc-strontium alloy is disclosed. The implant and/or device can include a biodegradable and cytocompatible magnesium-zinc-strontium (Mg—Zn—Sr) alloy having a weight percent composition of Zn and Sr as follows: 0.01≤Zn≤6 wt %, 0.01≤Sr≤3 wt %. A method for manufacturing an implant in the form of a biodegradable and cytocompatible magnesium-zinc-strontium alloy is disclosed, which includes melting the biodegradable and cytocompatible magnesium-zinc-strontium alloy in an inert environment and molding the biodegradable magnesium-zinc-strontium alloy in a semi-solid state.

First claim

What is claimed is:

1. A medical implant consisting of:
a biodegradable and cytocompatible magnesium-zinc-strontium alloy; and
a weight percent of zinc being 4.0 to 6.0, a weight percent of strontium being 0.01 to 0.15, and a balance of the medical implant being magnesium.

2. The medical implant according to claim 1 , wherein the implant is an orthopedic, dental, plastic surgical or vascular implant.

3. The medical implant according to claim 2 , wherein the orthopedic, dental, plastic surgical or vascular implant is a bone screw, a bone anchor, a tissue staple, a suture, a craniofacial, maxillofacial reconstruction plate, a fastener, a reconstructive dental implant, a medical fixation device, or an embolization material.

4. The medical implant according to claim 1 , wherein the implant is composed of only the biodegradable magnesium-zinc-strontium alloy.

5. The medical implant according to claim 1 , comprising:
a coating layer composed of the biodegradable magnesium-zinc-strontium alloy on a surface of the medical implant.

6. A medical implant consisting of:
a biodegradable and cytocompatible magnesium-zinc-strontium alloy, wherein the biodegradable and cytocompatible magnesium-zinc-strontium alloy has a weight percent composition of Zn and Sr as follows: 4.0≤Zn≤6.0 wt. %, 0.01≤Sr≤0.15 wt. %, and a balance of the medical implant being magnesium; and
wherein the implant is an orthopedic, dental, plastic surgical or vascular implant.

7. The medical implant according claim 6 , wherein the orthopedic, dental, plastic surgical or vascular implant is a bone screw, a bone anchor, a tissue staple, a suture, a craniofacial, maxillofacial reconstruction plate, a fastener, a reconstructive dental implant, a medical fixation device, or an embolization material.

8. The medical implant according to claim 6 , comprising:
a coating layer composed of the biodegradable magnesium-zinc-strontium alloy on a surface of the medical implant.

9. The medical implant according to claim 6 , wherein the biodegradable and cytocompatible magnesium-zinc-strontium alloy has a weight percent composition of 95.85 wt. % Mg, 4 wt. % Zn, and 0.15 wt. % Sr.

10. The medical implant according to claim 6 , wherein the biodegradable and cytocompatible magnesium-zinc-strontium alloy has a weight percent composition of 94.5-95.85 wt. % Mg, 4 wt. % Zn, and 0.01-0.15 wt. % Sr.

11. A medical implant consisting of:
a biodegradable and cytocompatible magnesium-zinc-strontium alloy, wherein the biodegradable and cytocompatible magnesium-zinc-strontium alloy has a weight percent of 91-95.84 wt. % Mg, 4.0-6.0 wt. % Zn, and 0.01-0.015 wt. % Sr.

12. The medical implant according to claim 11 , wherein the implant is an orthopedic, dental, plastic surgical or vascular implant.

13. The medical implant according claim 12 , wherein the orthopedic, dental, plastic surgical or vascular implant is a bone screw, a bone anchor, a tissue staple, a suture, a craniofacial, maxillofacial reconstruction plate, a fastener, a reconstructive dental implant, a medical fixation device, or an embolization material.

14. The medical implant according to claim 11 , comprising:
a coating layer composed of the biodegradable magnesium-zinc-strontium alloy on a surface of the medical implant or device.

Assignees

• Univ California

Inventors

• Liu Huinan
• Cipriano Aaron

Classifications

• C22C23/04

  with zinc or cadmium as the next major constituent · CPC title

• A61F2/00

  Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents (dental prostheses A61C13/00; artificial kidneys A61M1/14; artificial hearts A61M60/00) · CPC title

• B21C23/00

  Extruding metal; Impact extrusion · CPC title

• A61L27/306

  Other specific inorganic materials not covered by A61L27/303 - A61L27/32 · CPC title

• A61L27/04

  Metals or alloys · CPC title