Methods and compositions to graft bone using iron excipients
US-2024000996-A1 · Jan 4, 2024 · US
US10245614B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10245614-B2 |
| Application number | US-201514937075-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 10, 2015 |
| Priority date | Nov 11, 2014 |
| Publication date | Apr 2, 2019 |
| Grant date | Apr 2, 2019 |
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Disclosed is an imprinter device comprising an array of adjacent applicators that are arranged so that longitudinal axes of each of the adjacent applicators are parallel to each other, wherein the applicators are configured to make contact with and conform to a surface of a three dimensional (3D) object. In some embodiments, the applicators move independently of each other with respect to the surface of the object, and wherein the applicators are configured to apply a material over the object while in proximity to the surface of the object. Also disclosed are methods of conformal coating a surface of an object.
Opening claim text (preview).
What is claimed is: 1. An imprinter device comprising an array of adjacent applicators that are arranged so that longitudinal axes of each of the adjacent applicators are parallel to each other, wherein the applicators are configured to make contact with and conform to a surface of a three dimensional (3D) object, and wherein the applicators are configured to move independently of each other with respect to the surface of the object. 2. The imprinter device according to claim 1 , wherein the applicators are configured to apply a material to the object while in proximity to the surface of the object. 3. The imprinter device according to claim 1 , wherein the applicators are positioned in a pattern having an inter-applicator spacing of from 1-500 μm. 4. The imprinter device according to claim 3 , wherein the pattern is repeating grid pattern. 5. The imprinter device according to claim 1 , wherein the device is configured to apply a force to each of the applicators, wherein each of the applicators move perpendicularly towards the object along the longitudinal axes of the applicators, and wherein each of the applicators contact the surface of the object. 6. The imprinter device according to claim 5 , wherein the force applied to each applicator is provided by a device or system selected from the group consisting of a spring, a lever, a hydraulic system and an air pressure system. 7. The imprinter device according to claim 1 , wherein, at a given time, at least one applicator may dispense a material while other applicators do not dispense the same material. 8. The imprinter device according to claim 1 , wherein each applicator in the array of applicators is connected to a different supply line configured to conduct said material through each applicator. 9. The imprinter device according to claim 8 , wherein each applicator is individually matched to a corresponding, dedicated pump. 10. The imprinter device according to claim 1 , wherein the array of applicators is configured so that different applicators can dispense different types of material to the object. 11. The imprinter device according to claim 1 , wherein the array contains at least 10 applicators. 12. The imprinter device according to claim 1 , wherein the applicators are selected from the group consisting of a rod having a solid end that contacts the surface of the object, a hollow nozzle and an applicator comprising a nozzle. 13. The imprinter device according to claim 1 , wherein the type, speed, rate, and/or pattern of the dispensed material is controlled by a computer. 14. A method of conformal coating a surface of an object, the method comprising contacting the imprinter according to claim 1 with a surface of the object, wherein each applicator in the array of applicators conforms to a position of the surface of the object that the applicator contacts, and dispensing a material from one or more applicators in the array of applicators and so that the material is applied to the surface of the object at position(s) contacted by the applicator(s). 15. The method according to claim 14 , wherein the material is dispensed while each applicator in the array of applicators is in contact with the surface of the object. 16. The method according to claim 14 , wherein different applicators in the array of applicators dispense different types of material. 17. The method according to claim 14 , wherein the material dispensed from the one or more applicators comprises a biological macromolecule and/or a biological cell. 18. The method according to claim 17 , wherein said biological macromolecule is selected from the group consisting of a extracellular matrix protein, a growth hormone and a collagen. 19. The method according to claim 17 , wherein the material dispensed onto the object comprises a biological cell, and wherein the biological cell is cultured and grown in the object. 20. The method according to claim 14 wherein the material dispensed from the one or more applicators does not contain a biological macromolecule and/or a biological living cell. 21. The method according to claim 20 , wherein cross-linkable polymers or resins are dispensed from individually-controlled applicators at different pressures and/or rates. 22. The method according to claim 20 , wherein a dispensed cross-linkable polymer or resin is cross-linked by an ambient UV source. 23. The method according to claim 14 , wherein the object is a biological scaffold. 24. The method of claim 14 , wherein the object is a non-biological substrate.
Polyxylylenes · CPC title
Curing or cross-linking the coating · CPC title
Collagen · CPC title
Macromolecular compounds containing only carbon atoms in the main chain of the macromolecule, e.g. polyxylylenes · CPC title
Growth factors · CPC title
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