Mass spectrometer with laser system for producing photons of different energies

Patent metadata

Field	Value
Publication number	US-10236173-B2
Application number	US-201715820013-A
Country	US
Kind code	B2
Filing date	Nov 21, 2017
Priority date	Dec 20, 2016
Publication date	Mar 19, 2019
Grant date	Mar 19, 2019

Abstract

The invention relates to mass spectrometers with optically pumped lasers, whose laser light can be used for ionization by laser desorption, for the fragmentation of ions by photodissociation (PD), for the initiation of ion reactions, and for other purposes. The invention provides a laser system for a mass spectrometer, with which at least two laser beams of different wavelengths can be generated for use at different points along an ion path from an ion source to an ion detector in the mass spectrometer.

First claim

The invention claimed is:

1. Mass spectrometer having an ion source, an ion detector, an ion path from the ion source to the ion detector, and a laser system which comprises an optical pump system, an optically pumped laser cell to produce primary photons, and a multiplier system to condition the primary photons to a plurality of different photon energies, at least one of which is higher than an energy of the primary photons, wherein the laser system is designed such that the photons of different energies exiting the multiplier system are each guided to different points along the ion path.

2. The mass spectrometer according to claim 1 , wherein photons of a first energy which exit the multiplier system are guided to the ion source to at least one of desorb, ionize and post-ionize molecules.

3. The mass spectrometer according to claim 1 , wherein photons of a second energy which exit the multiplier system are guided to at least one of an ion guide and ion storage device on the ion path, in order to photodissociate ions guided or stored there.

4. The mass spectrometer according to claim 1 , wherein one of the photon energies after the conditioning corresponds to the primary photon energy, and another one of the photon energies after the conditioning is higher than the primary photon energy.

5. The mass spectrometer according to claim 1 , wherein the multiplier system has a plurality of multiplier paths through which the primary photons pass in order to be conditioned to different energies.

6. The mass spectrometer according to claim 5 , wherein the multiplier paths at least partially coincide spatially.

7. The mass spectrometer according to claim 6 , wherein the multiplier system has a multiplier path with a plurality of multiplier crystals, and the multiplier paths each branch off at different points in front of, between or behind the multiplier crystals.

8. The mass spectrometer according to claim 1 , wherein the primary photons are infrared photons.

9. The mass spectrometer according to claim 8 , wherein the multiplier system is designed to produce photons in at least one of the visible, near ultraviolet and far ultraviolet spectral region.

10. The mass spectrometer according to claim 1 , wherein the multiplier system is designed to at least one of (i) simultaneously condition primary photons using a beam splitter to different photon energies and (ii) condition a first sub-group of pulses from a sequence of primary photon pulses to a first photon energy, and condition a sub-group of pulses not identical with the first one to a second photon energy.

11. The mass spectrometer according to claim 1 , wherein the photons of a specific conditioned energy exiting the multiplier system pass through a delaying device before they are guided to the point along the ion path to arrive there at predetermined timing.

12. Method for operating a mass spectrometer which comprises an ion source, an ion detector, an ion path from the ion source to the ion detector, and a laser system, where a laser cell of the laser system is optically pumped to produce primary photons, and the primary photons pass through a multiplier system to be conditioned to a plurality of different photon energies, of which at least one is higher than an energy of the primary photons, wherein the photons of different photon energies exiting from the multiplier system are each guided to different points along the ion path.

13. The method according to claim 12 , wherein the photons of different energies are used for at least one of the vaporization of solid state or liquid molecules with or without their partial ionization, ionization of gaseous molecules, initiation of ion-molecule reactions, photodissociation of ions, separation of ion clusters, desolvation of ions and cleaning of surfaces along the ion path.

Assignees

• Bruker Daltonik Gmbh

Inventors

• Bossmeyer Jens
• Haase Andreas

Classifications

• H01J49/062 Primary

  Ion guides (linear ion traps performing mass selection H01J49/4225, mass filters H01J49/421) · CPC title

• H01J49/0031

  Step by step routines describing the use of the apparatus (H01J49/0081 takes precedence) · CPC title

• H01S3/115

  using intracavity electro-optic devices · CPC title

• H01J49/161 Primary

  using photoionisation, e.g. by laser · CPC title

• H01S3/0092

  Nonlinear frequency conversion, e.g. second harmonic generation [SHG] or sum- or difference-frequency generation outside the laser cavity (nonlinear frequency conversion per se G02F1/35) · CPC title