Miniature ion source of fixed geometry

Patent metadata

Field	Value
Publication number	US-10236171-B2
Application number	US-201415022396-A
Country	US
Kind code	B2
Filing date	Sep 17, 2014
Priority date	Sep 20, 2013
Publication date	Mar 19, 2019
Grant date	Mar 19, 2019

Abstract

A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

First claim

The invention claimed is:

1. A mass spectrometer comprising:
an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein said gas cone has a first longitudinal axis arranged along an x-axis;
an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds said first capillary tube;
a desolvation gas supply tube;
an analyte liquid supply arranged and adapted to supply an analyte liquid via said first capillary tube so that said liquid exits said outlet of said first capillary tube at a flow rate >200 μL/min; and
a nebulizer gas supply arranged and adapted to supply a nebuliser gas via said second capillary tube at a flow rate in the range 80-150 L/hr;
wherein an outlet of said first capillary tube is arranged at a distance x mm along said x-axis as measured from the centre of said gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of said gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of said gas cone inlet aperture;
wherein said x-axis, said y-axis and said z-axis are mutually orthogonal;
wherein:
said desolvation gas supply tube surrounds said second capillary tube;
and wherein said mass spectrometer further comprises:
a desolvation gas supply arranged and adapted to supply a desolvation gas via said desolvation gas supply tube at a flow rate in the range 400-1200 L/hr;
a heater arranged and adapted to heat said desolvation gas to a temperature ≥100° C.; and
a cone gas supply arranged and adapted to supply a cone gas to said gas cone at a flow rate in the range 40-80 L/hr;
wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1;
wherein the orientation of said Electrospray ion source relative to said atmospheric pressure interface is permanently fixed.

2. A mass spectrometer as claimed in claim 1 , wherein x falls within a range selected from the group consisting of: (i) 2-3 mm; (ii) 3-4 mm; (iii) 4-5 mm; (iv) 2.5-4.5 mm; and (v) 3.0-4.0 mm.

3. A mass spectrometer as claimed in claim 1 , wherein y falls within a range selected from the group consisting of: (i) 0.0-1.0 mm; (ii) 1.0-2.0 mm; (iii) 2.0-3.0 mm; (iv) 3.0-4.0 mm; and (v) 4.0-5.0 mm.

4. A mass spectrometer as claimed in claim 1 , wherein z falls within a range selected from the group consisting of: (i) 5-6 mm; (ii) 6-7 mm; (iii) 7-8 mm; (iv) 8-9 mm; (v) 9-10 mm; (vi) 10-11 mm; (vii) 11-12 mm; (viii) 12-13 mm; (ix) 13-14 mm; (x) 14-15 mm; (xi) 15-16 mm; (xii) 16-17 mm; (xiii) 17-18 mm; (xiv) 18-19 mm; (xv) 19-20 mm; (xvi) 20-21 mm; (xvii) 21-22 mm; (xviii) 22-23 mm; (xix) 23-24 mm; and (xx) 24-25 mm.

5. A mass spectrometer as claimed in claim 1 , wherein said first capillary tube protrudes from said second capillary tube by 0.5 mm±0.2 mm.

6. A mass spectrometer as claimed in claim 1 , wherein said first capillary tube protrudes from said desolvation gas supply tube by 1.2 mm±0.2 mm.

7. A mass spectrometer as claimed in claim 1 , wherein said second axis is arranged at an angle α relative to said z-axis, wherein α falls within a range selected from the group consisting of: (i) 0-1°; (ii) 1-2°; (iii) 2-3°; (iv) 3-4°; (v) 4-5°; (vi) 5-6°; (vii) 6-7°; (viii) 7-8°; (ix) 8-9°; (x) 9-10°; (xi) 10-11°; (xii) 11-12°; (xiii) 12-13°; (xiv) 13-14°; and (xv) 14-15 °.

8. A mass spectrometer as claimed in claim 1 , wherein said second axis is arranged at an angle β relative to said y-axis, wherein β falls within a range selected from the group consisting of: (i) 0-1°; (ii) 1-2°; (iii) 2-3°; (iv) 3-4°; (v) 4-5°; (vi) 5-6°; (vii) 6-7°; (viii) 7-8°; (ix) 8-9°; (x) 9-10°; (xi) 10-11°; (xii) 11-12°; (xiii) 12-13°; (xiv) 13-14°; and (xv) 14-15 °.

9. A mass spectrometer as claimed in claim 1 , wherein said second axis is arranged at an angle γ relative to said y-axis, wherein γ falls within a range selected from the group consisting of: (i) 0-1°; (ii) 1-2°; (iii) 2-3°; (iv) 3-4°; (v) 4-5°; (vi) 5-6°; (vii) 6-7°; (viii) 7-8°; (ix) 8-9°; (x) 9-10°; (xi) 10-11°; (xii) 11-12°; (xiii) 12-13°; (xiv) 13-14°; and (xv) 14-15°.

10. A mass spectrometer as claimed in claim 1 , wherein said cone gas and/or said desolvation gas and/or said nebuliser gas comprises nitrogen, sulphur hexafluoride (“SF6”), air or carbon dioxide.

11. A mass spectrometer as claimed in claim 1 , wherein said mass spectrometer comprises a miniature mass spectrometer.

12. A mass spectrometer comprising:
an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein said gas cone has a first longitudinal axis arranged along an x-axis;
an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds said first capillary tube;
a desolvation gas supply tube;
an analyte liquid supply arranged and adapted to supply an analyte liquid via said first capillary tube so that said liquid exits said outlet of said first capillary tube, wherein an analyte liquid flow rate of said analyte liquid supply is fixed;
a nebuliser gas supply arranged and adapted to supply a nebuliser gas via said second capillary tube, wherein a nebuliser gas flow rate of said nebuliser gas supply is fixed;
wherein an outlet of said first capillary tube is arranged at a distance x mm along said x-axis as measured from the centre of said gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of said gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of said gas cone inlet aperture;
wherein said x-axis, said y-axis and said z-axis are mutually orthogonal;
wherein:
said desolvation gas supply tube surrounds said second capillary tube;
and wherein said mass spectrometer further comprises:
a desolvation gas supply arranged and adapted to supply a desolvation gas via said desolvation gas supply tube, wherein a desolvation gas flow rate of said desolvation gas supply is fixed;
a heater arranged and adapted to heat said desolvation gas; and
a cone gas supply arranged and adapted to supply a cone gas to said gas cone, wherein a cone gas flow rate of said cone gas supply is fixed;
wherein the orientation of said Electrospray ion source relative to said atmospheric pressure interface is fixed.

13. A method of mass spectrometry comprising:
providing an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein said gas cone has a first longitudinal axis arranged along an x-axis;
providing an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds said first capillary tube;
supplying an analyte liquid via said first capillary tube so that said liquid exits said outlet of said first capillary tube at a flow rate >200 μL/min; and
supplying a nebuliser gas via said second capillary tube at a flow rate in the range 80-150 L/hr;
wherein an outlet of said first capillary tube is arranged at a distance x mm along said x-axis as measured from the centre of said gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of said gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of said gas cone inlet aperture; and
wherein said x-axis, said y-axis and said z-axis are mutually orthogonal;
wherein said method further comprises:
providing a desolvation gas supply tube which surrounds said second capillary tube;

supplying a desolvation gas via said desolvation gas supply tube at a

Assignees

• Micromass Ltd

Inventors

• Bajic Stevan
• Gordon David
• Kenny Daniel James
• Moulds Richard Barrington
• O'Brien Stephen
• Trivett Ian
• Whyatt Kate

Classifications

• H01J49/167 Primary

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title

• H01J49/0027

  Methods for using particle spectrometers · CPC title

• H01J49/165 Primary

  Electrospray ionisation · CPC title

• H01J49/044

  with means for preventing droplets from entering the analyzer; Desolvation of droplets · CPC title