Embolic devices

Patent metadata

Field	Value
Publication number	US-10232089-B2
Application number	US-201615252089-A
Country	US
Kind code	B2
Filing date	Aug 30, 2016
Priority date	Apr 18, 2011
Publication date	Mar 19, 2019
Grant date	Mar 19, 2019

Abstract

Described herein are apparatus, compositions, systems and associated methods to occlude structures and malformations of the vasculature with radiopaque hydrogel filaments with delayed controlled rates of expansion. Further described is a device for implantation in an animal comprising a difunctional, low molecular weight ethylenically unsaturated shapeable macromer; an ethylenically unsaturated monomer; and a radiopaque element, wherein said device contains no support members. Methods of forming such devices are also disclosed.

First claim

We claim:

1. A method of forming a polymeric filament, the method comprising:
polymerizing a solution to create a polymeric filament including about 25% w/w poly (ethylene glycol) 10,000 macromer, about 11% w/w of an ethylenically unsaturated monomer, and about 63% w/w barium sulfate,
wherein the polymeric filament is configured to be loaded into an introducer configured to be connected to a catheter.

2. The method of claim 1 , further comprising treating the polymeric filament in a non-physiological pH for a predetermined amount of time thereby creating an environmentally responsive filament.

3. The method of claim 2 , wherein the non-physiological pH is acidic.

4. The method of claim 2 , wherein the non-physiological pH is basic.

5. The method of claim 1 , wherein the polymerizing includes polymerization in a tube.

6. The method of claim 1 , wherein the at least one ethylenically unsaturated monomer is a pH sensitive monomer selected from acrylic acid, methacrylic acid, amino methacrylate, amino methacrylamide, or a combination thereof.

7. The method of claim 1 , wherein the polymeric filament has a diameter of less than about 0.03 inches.

8. The method of claim 1 , wherein the polymerization solution includes a multifunctional, ethylenically unsaturated cross-linker.

9. The method of claim 1 , wherein the polymeric filament is configured to be flushed from the introducer into a catheter using a first pressurized liquid having a pressure of between about 50 psi and about 200 psi.

10. The method of claim 9 , wherein the polymeric filament is configured to be flushed from the catheter using a second pressurized liquid having a pressure of between about 60 psi and about 140 psi.

11. A method of forming a hydrogel, the method comprising:
polymerizing a solution to create a polymeric filament including about 29% w/w poly (ethylene glycol) 10,000 macromer, about 12% w/w of an ethylenically unsaturated monomer, and about 58% w/w barium sulfate,
wherein the polymeric filament is configured to be loaded into an introducer configured to be connected to a catheter.

12. The method of claim 11 , further comprising treating the polymeric filament in a non-physiological pH for a predetermined amount of time thereby creating an environmentally responsive filament.

13. The method of claim 12 , wherein the non-physiological pH is acidic.

14. The method of claim 12 , wherein the non-physiological pH is basic.

15. The method of claim 11 , wherein the polymerizing includes polymerization in a tube.

16. The method of claim 11 , wherein the at least one ethylenically unsaturated monomer is a pH sensitive monomer selected from acrylic acid, methacrylic acid, amino methacrylate, amino methacrylamide, or a combination thereof.

17. The method of claim 11 , wherein the polymeric filament has a diameter of less than about 0.03 inches.

18. The method of claim 11 , wherein the polymerization solution includes a multifunctional, ethylenically unsaturated cross-linker.

19. The method of claim 11 , wherein the polymeric filament is configured to be flushed from the introducer into a catheter using a first pressurized liquid having a pressure of between about 50 psi and about 200 psi.

20. The method of claim 19 , wherein the polymeric filament is configured to be flushed from the catheter using a second pressurized liquid having a pressure of between about 60 psi and about 140 psi.

Assignees

• Terumo Corp

Inventors

• Constant Michael
• Garretson Josh
• Cruise Gregory M

Classifications

• A61B17/1214

  Coils or wires · CPC title

• A61L2430/36

  for embolization or occlusion, e.g. vaso-occlusive compositions or devices · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title

• A61B17/1215

  comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated · CPC title

• A61L31/048 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds (A61L31/041 takes precedence) · CPC title