Metal salt compositions
US-9486396-B2 · Nov 8, 2016 · US
US10226407B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10226407-B2 |
| Application number | US-201615393953-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 29, 2016 |
| Priority date | Dec 30, 2015 |
| Publication date | Mar 12, 2019 |
| Grant date | Mar 12, 2019 |
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Provided are aqueous soluble tin phosphate complexes formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt, e.g., sodium tripolyphosphate (Na 5 P 3 O 10 ), and oral care compositions comprising the complex and uses thereof.
Opening claim text (preview).
What is claimed is: 1. An oral care composition comprising an aqueous soluble tin phosphate complex formed from a mixture comprising tin (II) fluoride or tin (II) chloride and a tripolyphosphate salt; wherein the complex is formed in situ in an aqueous solution and combined with the composition; or is isolated from the aqueous solution in solid form and combined with the composition; or is lyophilized and combined with the composition; or is isolated with an anti-solvent and combined with the composition. 2. The composition of claim 1 , wherein the tripolyphosphate salt is sodium tripolyphosphate (Na 5 P 3 O 10 ). 3. The composition of claim 1 , wherein the complex is formed in situ in an aqueous solution and combined with the composition. 4. The composition of claim 3 , wherein the complex is isolated from the aqueous solution in solid form and combined with the composition. 5. The composition of claim 1 , wherein the complex is lyophilized and combined with the composition. 6. The composition of claim 1 , wherein the complex is isolated with an anti-solvent and combined with the composition. 7. The composition of claim 1 , wherein the complex is present in an amount of 2 to 30 weight % by weight of the composition. 8. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 1P:1Sn to less than 15P:1Sn. 9. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of greater than 2P:1Sn to less than 10P:1Sn. 10. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 2P:1Sn to 5P:1Sn. 11. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 3P:1Sn to 5P:1Sn. 12. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and the tripolyphosphate salt in a molar ratio of 5P:1Sn. 13. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 1P:1Sn to less than 15P:1Sn. 14. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of greater than 2P:1Sn to less than 10P:1Sn. 15. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 2P:1Sn to 5P:1Sn. 16. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 3P:1Sn to 5P:1Sn. 17. The composition of claim 1 , wherein the complex is formed from tin (II) fluoride or tin (II) chloride and sodium tripolyphosphate in a molar ratio of 5P:1Sn. 18. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 20 weight % tripolyphosphate salt by weight of the mixture. 19. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 10 weight % tripolyphosphate salt by weight of the mixture. 20. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 20 weight % sodium tripolyphosphate by weight of the mixture. 21. The composition of claim 1 , wherein the complex is formed from a mixture comprising 1 to 10 weight % tin (II) fluoride or tin (II) chloride by weight of the mixture and 1 to 10 weight % sodium tripolyphosphate by weight of the mixture. 22. The composition of claim 1 , wherein the composition comprises tin (II) fluoride. 23. The composition of claim 1 , wherein the composition comprises tin (II) chloride. 24. The composition of claim 1 , wherein the composition comprises an aqueous solution. 25. The composition of claim 1 further comprising more than 20 weight % water by weight of the composition. 26. The composition of claim 1 , wherein the composition is a mouthwash. 27. The composition of claim 1 for use to reduce dentinal hypersensitivity. 28. A method to reduce or inhibit dentinal hypersensitivity, dental caries, gingivitis, or plaque in a person in need thereof comprising applying an effective amount of an oral care composition as claimed in claim 1 to teeth of the person.
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