Embolization device constructed from expansile polymer

Patent metadata

Field	Value
Publication number	US-10226258-B2
Application number	US-201715635046-A
Country	US
Kind code	B2
Filing date	Jun 27, 2017
Priority date	Jun 15, 2006
Publication date	Mar 12, 2019
Grant date	Mar 12, 2019

Abstract

Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

First claim

We claim:

1. An occlusion device comprising:
an elongated hydrogel having a solid mass and a substantially continuous length, and
a flexible carrier member situated around the elongated hydrogel,
wherein the elongated hydrogel includes a polyether macromer, and
wherein the elongated hydrogel is configured to expand upon contact with an aqueous liquid.

2. The occlusion device of claim 1 , wherein the polyether macromer is poly(ethylene glycol) di-acrylamide, poly(ethylene glycol) di-acrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, a derivative thereof, or a combinations thereof.

3. The occlusion device of claim 2 , wherein the polyether macromer is poly(ethylene glycol) di-acrylamide.

4. The occlusion device of claim 1 , wherein the flexible carrier member is a coil or microcoil.

5. The occlusion device of claim 1 , wherein the flexible carrier member includes at least one gap configured to allow the elongated hydrogel to expand into the at least one gap.

6. The occlusion device of claim 4 , wherein the at least one gap is between 0.00025″ and 0.005″.

7. The occlusion device of claim 1 , further comprising a monomer including at least one pH sensitive ionizable functional group.

8. The occlusion device of claim 7 , wherein the at least one pH sensitive ionizable functional group includes a basic group or an acidic group.

9. The occlusion device of claim 8 , wherein the basic group comprises an amine, derivatives thereof, or combinations thereof.

10. The occlusion device of claim 8 , wherein the basic group is configured to be deprotonated at pHs greater than the pKa or protonated at pHs less than the pKa of the functional group.

11. The occlusion device of claim 8 , wherein the acidic group comprises a carboxylic acid, derivatives thereof, or combinations thereof.

12. The occlusion device of claim 8 , wherein the acidic group is configured to be protonated at pHs less than the pKa or de-protonated at pHs greater than the pKa of the functional groups.

13. The occlusion device of claim 7 , wherein the monomer is acrylic acid, methacrylic acid, or a salt thereof.

14. The occlusion device of claim 1 , wherein the elongated hydrogel is substantially free of acrylamide.

15. The occlusion device of claim 1 , wherein the polyether macromer is cross-linked with at least one ethylenically unsaturated compound.

16. The occlusion device of claim 1 , wherein the polyether macromer is cross-linked with N,N′-methylenebisacrylamide, derivatives thereof, or combinations thereof.

17. The occlusion device of claim 1 , wherein the elongated hydrogel comprises a reaction product of a monomer, the polyether macromer, and an initiator.

18. The occlusion device of claim 17 , wherein the initiator is N,N,N′,N′-tetramethylethylenediamine, ammonium persulfate, azobisisobutyronitrile, benzoyl peroxides, 2,2′-azobis(2-methylpropionamidine) dihydrochloride, a derivative thereof, or a combination thereof.

19. The occlusion device of claim 1 , wherein the elongated hydrogel is substantially non-resorbable.

20. The occlusion device of claim 1 , wherein the flexible carrier member is metallic or polymeric.

21. The occlusion device of claim 1 , wherein the elongated hydrogel includes pores.

Assignees

• Microvention Inc

Inventors

• Cruise Gregory M
• Constant Michael J
• Tran Terrance

Classifications

• A61L31/06

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title

• A61B17/12145

  having a pre-set deployed three-dimensional shape (methods of manufacturing A61B2017/00526) · CPC title

• A61B17/12168

  having a mesh structure (A61B17/1214 takes precedence) · CPC title

• A61B17/12113

  within an aneurysm · CPC title

• A61B17/1214

  Coils or wires · CPC title