Centrifugal microfluidic control systems and method for configuring the same

Patent metadata

Field	Value
Publication number	US-10220388-B2
Application number	US-201615231500-A
Country	US
Kind code	B2
Filing date	Aug 8, 2016
Priority date	Aug 8, 2016
Publication date	Mar 5, 2019
Grant date	Mar 5, 2019

Abstract

The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a microfluidic supporting unit coupled to the control unit in the centrifugal tube. The control unit may change an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.

First claim

What is claimed is:

1. A centrifugal microfluidics control system, comprising:
a centrifugal tube;
a centrifugal unit accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube;
a control unit fixed in the bottom of the centrifugal tube; and
a microfluidic supporting unit coupled to the control unit in the centrifugal tube, the microfluidic supporting unit and the control unit being arranged inside the tube,
wherein the control unit changes an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.

2. The system according to claim 1 , wherein the microfluidic supporting unit comprises a microfluidic supporting chip or microfluidic supporting cube.

3. The system according to claim 2 , wherein the microfluidic supporting chip or cube is made of polydimethylsiloxane.

4. The system according to claim 1 , wherein the centrifugal unit comprises:
a holder with a space receiving the centrifugal tube; and
an actuator configured to actuate the centrifugal unit to provide the centrifugal force.

5. The system according to claim 1 , wherein the system further comprises:
a communication unit communicating signals to the control unit, the control unit changing the orientation of the microfluidic supporting unit in response to the signals.

6. The system according to claim 5 , wherein the control unit comprises a wirelessly controlled stepper motor fixed in the bottom of the centrifugal unit.

7. The system according to claim 2 , wherein the microfluidic supporting chip comprises at least two microfluidic supporting layers.

8. The system according to claim 7 , wherein each of the microfluidic supporting layers comprises a plurality of chambers for accommodating samples and/or reagents and at least one passage allowing the samples and/or reagents to flow between the chambers.

9. The system according to claim 7 , wherein at least one channel is provided between adjacent microfluidic supporting layers to fluidly communicate the adjacent microfluidic supporting layers.

10. A method for configuring a centrifugal microfluidic system, comprising:
accommodating a centrifugal tube in a centrifugal unit for providing a centrifugal force to the centrifugal tube;
fixing a control unit into a bottom of the centrifugal tube;
coupling a microfluidic supporting unit to the control unit in the centrifugal tube, the microfluidic supporting unit and the control unit being arranged inside the tube; and
changing, by the control unit, an orientation of the microfluidic supporting unit to change a direction of the centrifugal force applied to the microfluidic supporting unit.

11. The method of claim 10 , wherein the microfluidic supporting unit comprises a microfluidic supporting chip with two or more microfluidic supporting layers, and the method further comprises:
placing the microfluidic supporting chip into the centrifugal tube.

12. The method of claim 11 , wherein the centrifugal unit comprises a holder and an actuator, and the method further comprises:
receiving the centrifugal tube into the holder; and
actuating the actuator to provide the centrifugal force.

13. The method of claim 10 , further comprising:
communicating signals to the control unit; and
changing the orientation of the microfluidic unit in response to the signals.

14. The method of claim 13 , wherein the control unit comprises a wirelessly controlled stepper motor fixed in the bottom of the centrifugal unit.

15. The method of claim 11 , further comprising:
providing samples to be treated and/or proper reagents on one of the microfluidic supporting layers;
transporting an intermediate product obtained from the samples and/or reagents to an adjacent one of the microfluidic supporting layers; and
providing other reagents on said adjacent one of the microfluidic supporting layers.

16. The method of claim 15 , further comprising:
forming a plurality of chambers on each of the microfluidic supporting layers for accommodating the samples and/or reagents; and
providing at least one passage between the plurality of chambers for allowing the samples and/or reagents to flow therebetween.

17. The method of claim 15 , wherein, the adjacent microfluidic supporting layers are configured with at least one channel therebetween to fluidly communicate the adjacent microfluidic supporting layers.

Assignees

• Univ Hong Kong Chinese
• Nanjing University Of Technology

Inventors

• Tang Minghui
• HO Ho-Pui
• Wang Guanghui
• KONG Siu-Kai
• LOO Fong-Chuen
• Kwok Ho Chin
• WU Shu-Yuen
• Zhang Xuping

Classifications

• B01L2300/0816

  Cards, e.g. flat sample carriers usually with flow in two horizontal directions · CPC title

• B01L2200/12

  Specific details about manufacturing devices · CPC title

• B01L2300/023

  Sending and receiving of information, e.g. using Bluetooth® · CPC title

• B04B5/0414

  comprising test tubes · CPC title

• B01L2300/0609

  Holders integrated in container to position an object · CPC title