Adjustment of sensory stimulation intensity to enhance sleep slow wave activity

Patent metadata

Field	Value
Publication number	US-10220183-B2
Application number	US-201414784746-A
Country	US
Kind code	B2
Filing date	Apr 1, 2014
Priority date	Apr 17, 2013
Publication date	Mar 5, 2019
Grant date	Mar 5, 2019

Abstract

A system is configured to provide sensory stimuli to a subject at a first intensity level, determine the effectiveness of the provided sensory stimuli, and incrementally increase the intensity level of the sensory stimuli based on the determined effectiveness. The effectiveness determination and the corresponding intensity increase are repeated one or more times during a given slow wave sleep episode. The system is configured to continue the effectiveness determinations and the corresponding intensity increases during the slow wave sleep episode until the intensity level reaches a maximum level, until an arousal level of the subject breaches an arousal level threshold, and/or until expiration of the period of slow wave sleep.

First claim

The invention claimed is:

1. A system configured to manage a current sleep session of a subject, the system comprising:
one or more sensory stimulators configured to provide sensory stimuli o the subject;
one or more sensors configured to generate output signals conveying information related to a current sleep stage of the subject during the current sleep session; and
one or more processors configured to execute computer program modules, the computer program modules comprising:
a sleep stage module configured to determine the current sleep stage of the subject based on the output signals, the sleep stage module configured to determine whether the subject is presently in slow wave sleep;
a slow wave sleep timing module configured to determine individual time periods of slow wave sleep during the current sleep session based on the sleep stage determinations by the sleep stage module;
a control module configured to control the one or more sensory stimulators to provide the sensory stimuli to the subject during the individual time periods of slow wave sleep, the control module configured to control the one or more sensory stimulators to provide the sensory stimuli at a first intensity level during a first individual time period of slow wave sleep;
an effectiveness module configured to determine an effectiveness of the provided sensory stimuli, the effectiveness being related to an increase in slow wave activity caused by the sensory stimuli, the effectiveness being determined based on the output signals, the effectiveness module configured to determine a first effectiveness of the sensory stimuli provided at the first intensity level during the first individual time period of slow wave sleep; and
an adjustment module configured to cause the one or more sensory stimulators to increase the first intensity level of the provided sensory stimuli based on the determined effectiveness such that the first intensity level of the provided sensory stimuli is increased by a first amount to a second intensity level based on the first effectiveness,
wherein the effectiveness module and the adjustment module are configured to repeat the effectiveness determination and the intensity increase one or more times during the individual time periods of slow wave sleep until expiration of the individual time periods such that the effectiveness module determines at least a second effectiveness of the sensory stimuli provided at the second intensity level during the first individual time period of slow wave sleep and the adjustment module causes the one or more sensory stimulators to increase the second intensity level of the provided sensory stimuli by a second amount to a third intensity level.

2. The system of claim 1 , wherein the sleep stage module is configured to determine one or more arousal levels of the subject during the individual time periods of slow wave sleep, and wherein the adjustment module is configured to cause the sensory stimulators to cease providing the sensory stimulation to the subject during a given period of slow wave sleep responsive to an arousal level determined by the sleep stage module breaching an arousal level threshold during the given period of slow wave sleep, the arousal level threshold determined by the sleep stage module based on one or more of the current sleep session, a previous sleep session of the subject, or information related to previous sleep sessions of other people, the other people corresponding demographically to the subject.

3. The system of claim 1 , wherein the sleep stage module is configured to determine one or more arousal levels of the subject during the individual time periods of slow wave sleep, and wherein the adjustment module is further configured to cause the one or more sensory stimulators to decrease the intensity of the sensory stimulation provided to the subject responsive to the arousal level of the subject breaching an arousal level threshold, the arousal level threshold determined by the sleep stage module based on one or more of the current sleep session, a previous sleep session of the subject, or information related to previous sleep sessions of other people, the other people corresponding demographically to the subject.

4. The system of claim 1 , wherein the adjustment module is configured to cause the sensory stimulators to increase the intensity level during a given time period of slow wave sleep until the intensity level reaches a maximum level.

5. The system of claim 1 , wherein the control module is configured such that the first intensity level is determined based on previous sleep sessions of the subject.

6. The system of claim 1 , wherein the adjustment module is configured such that the first amount and the second amount are different.

7. The system of claims 6 , wherein the adjustment module is configured such that the first amount and the second amount are determined during the first individual period of slow wave sleep.

8. A method for managing a current sleep session of a subject with a management system, the system comprising one or more sensory stimulators, one or more sensors, and one or more processors configured to execute computer program modules, the computer program modules comprising a sleep stage module, a slow wave sleep timing module, a control module, an effectiveness module, and an adjustment module, the method comprising:
generating, with the one or more sensors, output signals conveying information related to a current sleep stage of the subject during the current sleep session;
determining, with the sleep stage module, the current sleep stage of the subject based on the output signals;
determining, with the sleep stage module, whether the subject is presently in slow wave sleep based on the sleep stage determinations;
determining, with the slow wave sleep timing module, individual time periods of slow wave sleep during the current sleep session based on the sleep stage determinations;
controlling, with the control module, the one or more sensory stimulators to provide sensory stimuli to the subject during the individual time periods of slow wave sleep, the controlling including controlling the one or more sensory stimulators to provide the sensory stimuli at a first intensity level during a first individual time period of slow wave sleep;
determining, with the effectiveness module, an effectiveness of the provided sensory stimuli, the effectiveness being related to an increase in slow wave activity caused by the sensory stimuli, the effectiveness being determined based on the output signals such that a first effectiveness of the sensory stimuli provided at the first intensity level during the first individual time period of slow wave sleep is determined;
causing, with the adjustment module, the one or more sensory stimulators to increase the first intensity level of the provided sensory stimuli based on the determined effectiveness such that the first intensity level of the provided sensory stimuli is increased by a first amount to a second intensity level based on the first effectiveness; and
repeating, with the effectiveness module and the adjustment module, the effectiveness determination and the intensity increase one or more times during the individual time periods of slow wave sleep until expiration of the individual time periods such that a second effectiveness of the sensory stimuli provided at the second intensity level during the first individual time period of slow wave sleep is determined and the one or more sensory stimulators are caused to increase the second intensity level of the provided sensory stimuli by a second amount to a third intensity level.

9. The method of claim 8 , further comprising determining, with the sleep stage module, one

Assignees

• Koninklijke Philips Nv
• Wisconsin Alumni Res Found

Inventors

• Garcia Molina Gary Nelson
• Bellesi Michele
• Riedner Brady Alexander
• Tononi Giulio

Classifications

• A61B5/4812

  Detecting sleep stages or cycles · CPC title

• A61M2230/005

  Parameter used as control input for the apparatus · CPC title

• A61M2230/10

  Electroencephalographic signals · CPC title

• A61M2230/63

  Motion, e.g. physical activity · CPC title

• A61M2021/0044

  by the sight sense · CPC title