Fiber array for optical imaging and therapeutics

Patent metadata

Field	Value
Publication number	US-10220124-B2
Application number	US-201214002058-A
Country	US
Kind code	B2
Filing date	Feb 28, 2012
Priority date	Feb 27, 2009
Publication date	Mar 5, 2019
Grant date	Mar 5, 2019

Abstract

The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and include methods of treating cancer, methods of re-shaping or removing adipose tissue, and methods of delivering drugs or co-delivering drugs and energy to selected tissue.

First claim

The invention claimed is:

1. A microneedle device comprising:
one or more hollow core optical fiber microneedle having a core capable of conducting fluid and a tip adapted for piercing human tissue;
a light source;
and one or more solid core optical fiber;
wherein the light source and the solid core optical fiber are together disposed in a manner to deliver light into and through the hollow core optical fiber microneedle;
one or more fluid pump and one or more fluid reservoir disposed in a manner to facilitate aspiration of and delivery of fluids;
wherein the device is adapted to aspirate fluid into and to deliver fluid out through the tip and core of the hollow core optical fiber microneedle.

2. The microneedle device of claim 1 , wherein the tip is sharp, sharpened, tapered, angled, polished, or beveled.

3. The microneedle device of claim 1 wherein the one or more solid core optical fiber is disposed in communication with the hollow core optical fiber microneedle in a manner to allow light to pass from the solid core optical fiber to the hollow core optical fiber microneedle during use.

4. The microneedle device of claim 3 , wherein the solid core optical fiber and the hollow core optical fiber microneedle each have ends disposed facing one another.

5. The microneedle device of claim 4 , wherein the end of the solid core optical fiber and the end of the hollow core optical fiber microneedle contact one another.

6. The microneedle device of claim 4 , wherein the end of the solid core optical fiber and the end of the hollow core optical fiber microneedle do not contact one another.

7. The microneedle device of claim 1 comprising an outlet in the sheath for removing liquid from the sheath during use.

8. The microneedle device of claim 1 , wherein the hollow core optical fiber microneedle has an outside diameter in the range of about 50 μm to 500 μm.

9. The microneedle device of claim 1 comprising an inlet for delivering a fluid agent chosen from an anesthetic or anti-inflammatory agent.

10. The microneedle device of claim 1 , further comprising:
an elongated outer sheath with a wall defining a first lumen; and
wherein the hollow core optical fiber microneedle is disposed within the first lumen and provides a wall defining a second lumen;
wherein the light source and the solid core optical fiber are disposed in a manner to deliver light into and through the wall of the hollow core optical fiber microneedle; and
wherein the microneedle device is adapted to aspirate fluid into and deliver fluid out through the second lumen.

11. The microneedle device of claim 1 , wherein the light source and the solid core optical fiber are together disposed in a manner to deliver light into and through a wall of the hollow core optical fiber microneedle which surrounds the core capable of conducting fluid.

12. The microneedle device of claim 1 , wherein the solid core optical fiber is coupled with the hollow core optical fiber microneedle to deliver light from the light source at a coupling efficiency greater than 30%.

13. The microneedle device of claim 1 , wherein the solid core optical fiber is coupled with the hollow core optical fiber microneedle to deliver light from the light source such that the wavelength of emitted light is the same as the wavelength of the light source.

Assignees

• Rylander Christopher
• Kosoglu Mehmet A
• Hood Robert L
• Robertson John L
• Rossmeisl John H
• Grant David C
• Rylander Marissa N
• Virginia Tech Intellectual Properties Inc

Inventors

• Rylander Christopher
• Kosoglu Mehmet A
• Hood Robert L
• Robertson John L
• Rossmeisl John H
• Grant David C
• Rylander Marissa N

Classifications

• A61B2018/00452

  Skin · CPC title

• A61N2005/063

  comprising light transmitting means, e.g. optical fibres · CPC title

• A61N2005/0612

  using probes penetrating tissue; interstitial probes · CPC title

• A61B2018/00464

  Subcutaneous fat, e.g. liposuction, lipolysis · CPC title

• A61B2018/00476

  Hair follicles · CPC title