Water-soluble esterified cellulose ethers having a low degree of neutralization

Patent metadata

Field	Value
Publication number	US-10214594-B2
Application number	US-201615550097-A
Country	US
Kind code	B2
Filing date	Mar 8, 2016
Priority date	Mar 16, 2015
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

An esterified cellulose ether comprising aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, R being a divalent hydrocarbon group, has the following properties: i) the degree of neutralization of the groups —C(O)—R—COOH is not more than 0.4, ii) the total degree of ester substitution is from 0.10 to 0.70, and iii) the esterified cellulose ether has a solubility in water of at least 2.0 weight percent at 2 C.

First claim

The invention claimed is:

1. A hydroxypropyl methyl cellulose acetate succinate comprising acetyl groups and succinoyl groups, wherein
i) the degree of neutralization of the succinoyl groups is not more than 0.4,
ii) the total degree of ester substitution is from 0.10 to 0.70, and
iii) the hydroxypropyl methyl cellulose acetate succinate has a solubility in water of at least 2.0 weight percent at 2° C.

2. The hydroxypropyl methyl cellulose acetate succinate of claim 1 wherein the total degree of ester substitution is from 0.20 to 0.60.

3. The hydroxypropyl methyl cellulose acetate succinate of claim 1 having a degree of substitution of acetyl groups of from 0.25 to 0.69 or a degree of substitution of succinoyl groups of from 0.05 to 0.45.

4. The hydroxypropyl methyl cellulose acetate succinate of claim 1 wherein at least 85 wt. % of the hydroxypropyl methyl cellulose acetate succinate is soluble in a mixture of 2.5 weight parts of the hydroxypropyl methyl cellulose acetate succinate and 97.5 weight parts of water at 2° C.

5. The hydroxypropyl methyl cellulose acetate succinate of claim 4 wherein at least 90 wt. % of the hydroxypropyl methyl cellulose acetate succinate is soluble in a mixture of 2.5 weight parts of the hydroxypropyl methyl cellulose acetate succinate and 97.5 weight parts of water at 2° C.

6. An aqueous composition comprising the hydroxypropyl methyl cellulose acetate succinate of claim 1 dissolved in an aqueous liquid.

7. The aqueous composition of claim 6 comprising at least 10 weight percent of dissolved esterified cellulose ether, based on the total weight of the aqueous composition.

8. A liquid composition comprising at least one hydroxypropyl methyl cellulose acetate succinate of claim 1 and an organic diluent.

9. A process for coating a dosage form comprising the step of contacting an aqueous composition comprising the hydroxypropyl methyl cellulose acetate succinate of claim 1 dissolved in an aqueous liquid with the dosage form.

10. A process for the manufacture of capsule shells comprising the step of contacting an aqueous composition comprising the hydroxypropyl methyl cellulose acetate succinate of claim 1 dissolved in an aqueous liquid with dipping pins.

11. A coated dosage form wherein the coating comprises at least one hydroxypropyl methyl cellulose acetate succinate of claim 1 .

12. A polymeric capsule shell comprising at least one hydroxypropyl methyl cellulose acetate succinate of claim 1 .

13. A capsule comprising a capsule shell of claim 12 and further comprising a drug or a nutritional or food supplement or a combination thereof.

14. A solid dispersion of at least one active ingredient in at least one hydroxypropyl methyl cellulose acetate succinate of claim 1 .

Assignees

• Dow Global Technologies Llc

Inventors

• Petermann Oliver
• Knarr Matthias
• Appell Robert B

Classifications

• A61K9/4816

  Wall or shell material · CPC title

• A61K9/4866

  Organic macromolecular compounds · CPC title

• C08B11/20 Primary

  Post-etherification treatments of chemical or physical type, {e.g. mixed etherification in two steps}, including purification · CPC title

• C08B13/00 Primary

  Preparation of cellulose ether-esters · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title