Rigid stiffener-reinforced flexible neural probes, and methods of fabrication using wicking channel-distributed adhesives and tissue insertion and extraction

Patent metadata

Field	Value
Publication number	US-10214001-B2
Application number	US-201314376557-A
Country	US
Kind code	B2
Filing date	Feb 4, 2013
Priority date	Feb 3, 2012
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

A stiffener-reinforced microelectrode array probe and fabrication method using wicking channel-distributed adhesives which temporarily adheres a flexible device onto a rigid stiffener for insertion and extraction. Assembly is by dispensing a liquid adhesive into a narrow open groove wicking channel formed on the stiffener so that the adhesive is wicked along and tills the channel by capillary action, and adhering the adhesive-filled bonding side of the elongated section of the rigid substrate to a flexible device.

First claim

We claim:

1. A method of assembling a rigid substrate onto a flexible device comprising:
providing a rigid substrate having an elongated section with a bonding side, and a narrow open groove channel formed on the bonding side adjacent an interface surface of the bonding side;
dispensing one or more adhesive pellets into the narrow open groove channel, and melting the one or more adhesive pellets into a liquid phase so that the liquid-phase adhesive wicks along and completely fills the narrow open groove channel by capillary action; and
positioning a flexible device adjacent the interface surface of the rigid substrate so as to wick adhesive from the narrow open groove channel to a space in-between the flexible device and the interface surface of the rigid substrate and adhere the flexible device to the interface surface of the bonding side of the elongated section of the rigid substrate.

2. The method of claim 1 ,
further comprising heating the adhesive to improve wicking by decreasing its viscosity.

3. A method of assembling a rigid substrate onto a flexible device comprising: providing a rigid substrate having an elongated section with a bonding side, and a narrow open groove channel formed on the bonding side adjacent an interface surface of the bonding side, wherein the rigid substrate has a tab section connected to the elongated section, and a reservoir cavity formed on the tab section that is in fluidic communication with the narrow open groove channel; dispensing one or more adhesive pellets into the reservoir cavity of the tab section, and melting the one or more adhesive pellets into a liquid phase so that the liquid-phase adhesive wicks along and completely fills the reservoir cavity and the narrow open groove channel by capillary action; and positioning a flexible device adjacent the interface surface of the rigid substrate so as to wick adhesive from the narrow open groove channel to a space in-between the flexible device and the interface surface of the rigid substrate and adhere the flexible device to the interface surface of the adhesive filled bonding side of the elongated section of the rigid substrate.

4. The method of claim 3 ,
wherein the reservoir cavity is an open cavity having a receiving end.

5. A method of assembling a rigid substrate onto a flexible device comprising:
providing a rigid substrate having an elongated section, and a narrow open groove channel formed on a bonding side of the elongated section;
dispensing a liquid adhesive into the narrow open groove channel so that the adhesive is wicked along and fills the narrow open groove channel by capillary action, wherein the step of dispensing the liquid adhesive into the narrow open groove channel includes: dispensing one or more adhesive pellets into the narrow open groove channel, and melting the one or more adhesive pellets into a liquid phase so that the liquid-phase adhesive wicks along and fills the narrow open groove channel;
re-solidifying the liquid-phase adhesive into a solid phase in the narrow open groove channel; and
adhering the adhesive-filled bonding side of the elongated section of the rigid substrate to a flexible device, wherein the adhering step includes aligning the rigid substrate with the flexible device, followed by re-melting the solid-phase adhesive into the liquid phase to conformably contact the flexible device, and followed by re-solidifying the liquid-phase adhesive so as to adhere the adhesive-filled bonding side of the elongated section of the rigid substrate to the flexible device.

Assignees

• Lawrence Livermore Nat Security
• L Livermore Nat Security Llc

Inventors

• Shah Kedar G
• George Diane
• Pannu Satinderpall S
• Felix Sarah

Classifications

• A61B5/24 Primary

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• B32B37/1284 Primary

  Application of adhesive · CPC title

• Y10T156/10

  Methods of surface bonding and/or assembly therefor · CPC title

• A61N1/0551

  Spinal or peripheral nerve electrodes · CPC title

• A61B90/11

  with guides for needles or instruments, e.g. arcuate slides or ball joints · CPC title