Blood purification column

Patent metadata

Field	Value
Publication number	US-10213543-B2
Application number	US-201414765386-A
Country	US
Kind code	B2
Filing date	Feb 7, 2014
Priority date	Feb 12, 2013
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

A blood purification column includes an adsorbent and a casing whose two ends are open ends, wherein the adsorbent is housed inside the casing, and wherein one of two casing ends is a blood inflow-side end portion and another is a blood outflow-side end portion, and wherein a filter is disposed at the blood inflow-side end portion and/or the blood outflow-side end portion of the casing, and wherein the filter satisfies (1)-(3):
(1) an opening rate thereof is greater than or equal to 5% and less than or equal to 80%; (2) an equivalent diameter of an aperture thereof is greater than or equal to 1 μm and less than or equal to 5000 μm; (3) a ratio of the equivalent diameter of the aperture thereof to an average circle equivalent diameter of void spaces of the adsorbent is greater than or equal to 45%.

First claim

The invention claimed is:

1. A blood purification column comprising an adsorbent and a casing whose two ends are open ends, wherein the adsorbent is housed inside the casing, and wherein one of two casing ends is a blood inflow-side end portion and the other of the two casing ends is a blood outflow-side end portion, and wherein a mesh filter is disposed at the blood inflow-side end portion and/or the blood outflow-side end portion of the casing, and wherein the mesh filter satisfies (1)-(6):
(1) an opening rate thereof is greater than or equal to 21% and less than or equal to 66%;
(2) an equivalent diameter of an aperture thereof is greater than or equal to 10 μm and less than or equal to 400 μm;
(3) a ratio of the equivalent diameter of the aperture thereof to an average circle equivalent diameter of void spaces of the adsorbent is greater than or equal to 56% and less than or equal to 220%;
(4) the absorbent is in a hollow yarn and/or a solid yarn form;
(5) the adsorbent is disposed parallel to a column lengthwise direction; and
(6) a surface area of a portion open in a perpendicular direction relative to a lengthwise direction in the column is B 1 and a total surface area of a portion open in a parallel direction relative to the lengthwise direction in the column is B 2 , wherein B 1 /B 2 ≥1.

2. The blood purification column according to claim 1 , wherein the mesh filter contains at least one kind of raw material selected from the group consisting of a polyolefin-based resin, a polyamide-based resin and a fluorine-based resin.

3. The blood purification column according to claim 1 , wherein a filling factor of the adsorbent in a housing space in the column is greater than or equal to 30% and less than 70%.

4. The blood purification column according to claim 1 , wherein a yarn diameter or an outside diameter of the hollow yarn or solid yarn is greater than or equal to 10 μm and less than or equal to 1000 μm.

5. The blood purification column according to claim 1 , connected in series to an artificial kidney.

6. The blood purification column according to claim 2 , wherein a form of the adsorbent is a hollow yarn state and/or a solid yarn state.

7. The blood purification column according to claim 6 , wherein the adsorbent in the hollow yarn state and/or the solid yarn state is disposed parallel with a column lengthwise direction.

8. The blood purification column according to claim 1 , wherein the form of the adsorbent is a solid yarn state.

Assignees

• Toray Industries

Inventors

• Fujieda Hiroaki
• Ueno Yoshiyuki
• Tanaka Kazumi

Classifications

• B01J20/2805

  Sorbents inside a permeable or porous casing, e.g. inside a container, bag or membrane · CPC title

• A61M1/3627 Primary

  Degassing devices; Buffer reservoirs; Drip chambers; Blood filters · CPC title

• B01J20/26

  Synthetic macromolecular compounds · CPC title

• B01J20/261

  obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F) · CPC title

• B01J20/28023

  Fibres or filaments (fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence) · CPC title