Polymer film and antiadhesive material using the same

Patent metadata

Field	Value
Publication number	US-10213530-B2
Application number	US-201615534188-A
Country	US
Kind code	B2
Filing date	Jun 17, 2016
Priority date	Jun 19, 2015
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

A polymer film can be adjusted to movement or a fine uneven surface of a living body and has excellent ability to adhere to a biological tissue. The polymer film includes a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein the polymer film has a film thickness of 10 to 1000 nm. The branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule, the mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%, and a value obtained by dividing the average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000.

First claim

The invention claimed is:

1. A polymer film comprising a block copolymer having a structure in which branched polyalkylene glycol and polyhydroxyalkanoic acid are bound to each other, wherein
the branched polyalkylene glycol has at least three terminal hydroxyl groups per molecule,
mass percentage of the branched polyalkylene glycol relative to the total mass of the block copolymer is 1% to 30%,
a value obtained by dividing average molecular weight of polyhydroxyalkanoic acid in the block copolymer by X that is the number of terminal hydroxyl groups present per a single molecule of the branched polyalkylene glycol is 10000 to 30000, and
the polymer film is two dimensional and has a film thickness of 80 to 400 nm.

2. The polymer film according to claim 1 , wherein the branched polyalkylene glycol has a structure in which linear polyethylene glycol is bound to polyalcohol.

3. The polymer film according to claim 1 , wherein the branched polyalkylene glycol has 3 to 8 terminal hydroxyl groups.

4. The polymer film according to claim 1 , wherein the branched polyalkylene glycol has an average molecular weight of 5000 to 30000.

5. The polymer film according to claim 1 , wherein the block copolymer has an average molecular weight of 40000 to 200000.

6. The polymer film according to claim 1 , wherein the block copolymer is represented by formula (I):

where m denotes an integer of 0 to 4, each of n, o, p, q, and r independently denotes an integer of 36 to 126, each of v, w, x, y, and z independently denotes an integer of 91 to 376 or formula (II):
C CH 2 O CH 2 CH 2 O s COCH(CH 3 )O t H] 4   (II)

where s denotes an integer of 81 to 126, and t denotes an integer of 220 to 377.

7. The polymer film according to claim 1 , wherein the Young's modulus is 20 MPa to 700 MPa.

8. The polymer film according to claim 1 , having a receding contact angle less than 60°.

9. A laminated film, wherein a water-soluble film comprising a water-soluble polymer is laminated on at least one side of the polymer film according to claim 1 .

10. An antiadhesive material comprising a laminated film according to claim 9 .

11. An antiadhesive material comprising the polymer film according to claim 1 .

Assignees

• Toray Industries
• Nanotheta Co Ltd

Inventors

• Saito Akihiro
• Arakane Toru
• Tanahashi Kazuhiro
• Okabayashi Koji
• Takeoka Shinji
• Fujie Toshinori
• Suzuki Shoichiro
• Murata Atsushi
• Otsubo Shinya

Classifications

• C08G65/3311

  containing a hydroxy group · CPC title

• C08J5/18

  Manufacture of films or sheets · CPC title

• C08L2203/02

  for biomedical use · CPC title

• C08L53/005

  Modified block copolymers · CPC title

• C08G65/332 Primary

  containing carboxyl groups, or halides, or esters thereof · CPC title