Composition and uses thereof
US-2016144011-A1 · May 26, 2016 · US
US10213502B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10213502-B2 |
| Application number | US-201715607203-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 26, 2017 |
| Priority date | Dec 2, 2011 |
| Publication date | Feb 26, 2019 |
| Grant date | Feb 26, 2019 |
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The invention provides compositions and methods for preventing or reducing the severity of malaria.
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The invention claimed is: 1. A method of treating P. falciparum malaria in a subject or vaccinating against malaria comprising administering to the subject a composition comprising a purified PfGARP polypeptide antigen comprising the amino acid sequence of SEQ ID NO: 27 or a purified antigenic fragment thereof comprising the amino acid sequence of SEQ ID NO: 26. 2. The method of claim 1 , wherein said purified antigen or antigenic fragment thereof comprising the amino acid sequence of SEQ ID NO: 26 elicits an antibody immune response against PfGARP. 3. The method of claim 1 , wherein said subject is at least about 6-8 weeks of age. 4. The method of claim 1 , wherein said subject is an adolescent female or a female of childbearing age. 5. The method of claim 1 , wherein said composition is administered intramuscularly. 6. The method of claim 1 , further comprising administering a second vaccine. 7. The method of claim 6 , said second vaccine comprises RTS,S (Mosquirix) or MSP-1.
characterised by the host/recipient, e.g. newborn with maternal antibodies · CPC title
against material not provided for elsewhere {, e.g. haptens, metals, DNA, RNA, amino acids} · CPC title
Plasmodium · CPC title
Hemosporidia antigens, e.g. Plasmodium antigens · CPC title
Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues · CPC title
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