Pharmaceutical compositions containing steviosides

Patent metadata

Field	Value
Publication number	US-10213452-B2
Application number	US-201515523591-A
Country	US
Kind code	B2
Filing date	Oct 28, 2015
Priority date	Oct 31, 2014
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

The present invention relates to pharmaceutical compositions containing steviol glycoside and or steviol glycoside derivatives as well as to their use as osmotics in particular for use in the treatment of chronic renal failure by dialysis.

First claim

The invention claimed is:

1. A steviol glycoside-derivative of the general structure I

wherein one of R1 and R2 is a polyethylene glycol unit polyethylene glycol unit —(CH 2 —CH 2 —O) n —CH 2 —CH 2 —OH with n being an integer from 0 to 500, and one of R1 and R2 is H, a linear or branched C 1 to C 6 alkyl group, a polyethylene glycol unit —(CH 2 —CH 2 —O—) n —CH 2 —CH 2 —OH with n being an integer from 0 to 500, or one or more glucose, xylose or rhamnose units.

2. The steviol glycoside derivative according to claim 1 , wherein the steviol is selected from the group consisting of Steviolbiosid, Steviosid, Rebaudiosid A, Rebaudiosid B, Rebaudiosid C, Rebaudiosid D, Rebaudiosid E, Rebaudiosid F and Dulkosid A.

3. The steviol glycoside derivative according to claim 1 , wherein n is an integer from 0 to 100.

4. The steviol glycoside derivative according to claim 3 , wherein n=0.

5. The steviol glycoside derivative according to claim 1 , wherein one of R1 and R2 is a methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, tert-butyl, n-pentyl, or n-hexyl group.

6. The steviol glycoside derivative according to claim 1 , wherein R1 is a methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl, tert-butyl, n-pentyl, or n-hexyl group.

7. A dialysis solution containing at least one steviol glycoside derivative of the general structure according to claim 1 .

8. A kit configured for preparing the dialysis solution according to claim 7 , comprising a first component, a second component, and optionally one or more additional components, wherein said dialysis solution is obtained by mixing the first component with the second component and optionally with the additional component(s), and wherein the first or second component comprises the steviol glycoside derivative.

9. A kit according to claim 8 , comprising a first component, a second component, and a third component, wherein said dialysis solution is obtained by mixing the first component with the second and the third component, and wherein the first or second component comprises the steviol glycoside derivative.

10. A kit according to claim 9 comprising
the first component with a pH≤6.5,
the second component with a pH≥7.5 and
the third component with a pH of about 7.

11. A solid composition configured for preparing the dialysis solution according to claim 7 , wherein the dialysis solution is obtained by dissolving the solid composition in a solvent, and wherein the solid composition comprises the steviol glycoside derivative.

12. In a method of treating a patient for renal failure comprising dialysis of the patient's blood using a dialysis solution, the improvement comprising using the dialysis solution of claim 7 .

13. The steviol glycoside according to claim 1 wherein R1 and R2 are independently a polyethylene glycol unit —(CH2-CH2-O-)n-CH2-CH2-OH with n being an integer from 0 to 500.

Assignees

• Fresenius Medical Care Deutschland Gmbh

Inventors

• Aguilera Peralta Abelardo Isaac
• Lopez-Cabrera Manuel
• Selgas Gutierrez Rafael
• Steppan Sonja
• Passlick-Deetjen Jutta

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• C07H15/24

  Condensed ring systems having three or more rings · CPC title

• A61K31/704 Primary

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• A61P13/12

  of the kidneys · CPC title