Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof

Patent metadata

Field	Value
Publication number	US-10213384-B2
Application number	US-201815883134-A
Country	US
Kind code	B2
Filing date	Jan 30, 2018
Priority date	Apr 28, 2009
Publication date	Feb 26, 2019
Grant date	Feb 26, 2019

Abstract

The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.

First claim

What is claimed is:

1. A non-aqueous composition formulated for skin delivery of an active agent comprising:
a minocycline in a therapeutically effective amount of about 1% to about 5% by weight of the composition;
a short chain alcohol comprising ethanol present in an amount of at least 55% by weight of the composition;
about 12% to about 50% by weight of the composition of a protic polar solvent comprising propylene glycol;
a polymeric agent comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present in an amount ranging from about 0.5% to about 1% by weight of the composition;
a modulating agent comprising an antioxidizing agent present in an amount ranging from about 0.1% to about 10% by weight of the composition;
a metal; and
an essential oil,
wherein the composition is surfactant free, non-aqueous, and free or essentially free of fatty alcohol.

2. The non-aqueous composition according to claim 1 , wherein the minocycline is dissolved in the composition.

3. The non-aqueous composition according to claim 2 , wherein the minocycline is a minocycline hydrochloride.

4. The non-aqueous composition according to claim 1 , wherein the protic polar solvent is about 12% to about 30% by weight of the composition.

Assignees

• Foamix Pharmaceuticals Ltd

Inventors

• Tamarkin Dov
• Schuz David
• Berman Tal
• Hazot Yohan

Classifications

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P17/00

  Drugs for dermatological disorders · CPC title

• A61K8/46

  containing sulfur (A61K8/44 takes precedence) · CPC title

• A61K47/14

  Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title