2,3-dihydrobenzo[b]thiophene derivatives as hypoxia inducible factor-2(alpha) inhibitors
US-12171741-B2 · Dec 24, 2024 · US
Inhibitors of HIF prolyl hydroxylase
US10208060B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10208060-B2 |
| Application number | US-201515513854-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 23, 2015 |
| Priority date | Sep 28, 2014 |
| Publication date | Feb 19, 2019 |
| Grant date | Feb 19, 2019 |
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Abstract
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The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
First claim
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What is claimed is: 1. A compound which is: 2-(4-Hydroxy-2-oxo-1-(4-(trifluoromethyl)phenyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(1-(4-chlorophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(1-(4-fluorophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(4-hydroxy-2-oxo-1-phenyl-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(4-hydroxy-1-(4-methoxyphenyl)-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(4-hydroxy-2-oxo-1-(4-(trifluoromethoxy)phenyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(4-hydroxy-2-oxo-1-(m-tolyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(4-hydroxy-2-oxo-1-(p-tolyl)-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; 2-(1-(4-cyanophenyl)-4-hydroxy-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; and 2-(4-hydroxy-1-(5-methoxypyridin-2-yl)-2-oxo-1,2,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxamido)acetic acid; or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition comprising a compound of claim 1 and pharmaceutically acceptable carrier. 3. A method for the treatment of anemia in a mammal which comprises administering to the mammal an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof.
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the oxygen-containing ring being five-membered · CPC title
- C07D495/04Primary
Ortho-condensed systems · CPC title
Antianaemics · CPC title
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- What does patent US10208060B2 cover?
- The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound …
- Who is the assignee on this patent?
- Cai Jiaqiang, Crespo Alejandro, Debenham John, and 8 more
- What technology area does this patent fall under?
- Primary CPC classification C07D495/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).