Functional device and method of manufacturing the same

Patent metadata

Field	Value
Publication number	US-10207264-B2
Application number	US-201314432068-A
Country	US
Kind code	B2
Filing date	Sep 27, 2013
Priority date	Sep 28, 2012
Publication date	Feb 19, 2019
Grant date	Feb 19, 2019

Abstract

A functional device (and a functional device manufacturing method) includes a first substrate in which a groove is formed in one surface, a second substrate which is integrally disposed by bonding one surface of the second substrate to the one surface of the first substrate, and forms a flow path together with the groove of the first substrate, at least one modification object of a capture body which captures a target substance supplied into the flow path, an electrode which imparts an electrical or a chemical action to the target substance, and a catalyst, in which the modification object is disposed by being modified on a part of an inner surface of the flow path, a bonding portion between the one surface of the first substrate and the one surface of the second substrate is formed by bonding fluorine to silica.

First claim

What is claimed is:

1. A functional device, comprising:
a first substrate which has a groove formed on one surface of the first substrate;
a second substrate which is integrally disposed with the first substrate by bonding one surface of the second substrate and the one surface of the first substrate, and forms a flow path together with the groove of the first substrate; and
one of a capture body which is configured to capture a target substance supplied into the flow path, an electrode which is configured to impart an electrical or a chemical action to the target substance, and a catalyst, in which the one is disposed on a part of an inner surface of the flow path, wherein
each of the first substrate and the second substrate is a glass substrate,
a bonding portion between the one surface of the first substrate and the one surface of the second substrate includes F—Si bonds where fluorine is bonded to silica included in at least one substrate, and
said bonding portion between the one surface of the first substrate and the one surface of the second substrate has a fluorine concentration of greater than or equal to 0.6 at % and less than or equal to 3.5 at %.

2. The functional device according to claim 1 ,
wherein the flow path is a fine flow path of a microscale or a nanoscale.

3. The functional device according to claim 1 ,
wherein a bonding strength of the bonding portion is greater than or equal to 0.5 J/m 2 .

4. The functional device according to claim 1 ,
wherein the bonding portion is formed to have pressure resistance performance in which a sample solution is not leaked even when a pressure of the sample solution including the target substance which is pressurized and supplied to the flow path is 2000 kPa.

5. The functional device according to claim 1 ,
wherein the capture body is formed of a silane coupling agent.

6. A method of manufacturing a functional device, comprising:
forming a groove on one surface of a first substrate;
arranging at least one of a capture body which is configured to capture a target substance supplied into the flow path, an electrode which is configured to impart an electrical or a chemical action to the target substance, and a catalyst in a position corresponding to an inner surface of the flow path which is formed of the groove and one surface of a second substrate at the time of bonding the first substrate and the second substrate;
exposing oxygen plasma and supplying fluorine to at least one of the one surface of the first substrate and the one surface of the second substrate, and adjusting hydrophilic properties of the one surface; and
a step of bonding the one surface of the first substrate and the one surface of the second substrate forming a bonding portion while maintaining a temperature at which the capture body, electrode or catalyst is not thermally damaged,
the bonding portion between the one surface of the first substrate and the one surface of the second substrate including F—Si bonds where fluorine is bonded to silica included in at least one substrate, and
the bonding portion between the one surface of the first substrate and the one surface of the second substrate having a fluorine concentration of greater than or equal to 0.6 at % and less than or equal to 3.5 at % wherein each of the first substrate and the second substrate is a glass substrate.

7. The method of manufacturing the functional device according to claim 6 ,
wherein the flow path is a fine flow path of a microscale or a nanoscale.

8. The method of manufacturing the functional device according to claim 6 ,
wherein a contact angle of water in at least any one of the one surface of the first substrate and the one surface of the second substrate before being joined is from 10 degrees to 50 degrees.

9. The method of manufacturing the functional device according to claim 6 ,
wherein the temperature is 25° C. to 100° C.

10. The method of manufacturing the functional device according to claim 6 , wherein the capture body is formed of a silane coupling agent.

11. A method of detecting a target substance by using the functional device according to claim 1 , comprising:
injecting a sample solution including a target substance into the flow path; and
detecting a target substance captured in the flow path.

Assignees

• Japan Science & Tech Agency

Inventors

• Kitamori Takehiko
• Mawatari Kazuma

Classifications

• B01L2300/12

  Specific details about materials · CPC title

• B01L2300/0645

  Electrodes · CPC title

• B01L2300/161

  Control and use of surface tension forces, e.g. hydrophobic, hydrophilic · CPC title

• B01L2200/0689

  Sealing · CPC title

• B01L2300/0896

  Nanoscaled · CPC title