Compositions and methods for treatment of hyperplasia
US-2015190519-A1 · Jul 9, 2015 · US
Prion free nanoparticle compositions and methods of making thereof
US10206887B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10206887-B2 |
| Application number | US-201615239680-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 17, 2016 |
| Priority date | Apr 15, 2009 |
| Publication date | Feb 19, 2019 |
| Grant date | Feb 19, 2019 |
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- Title
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Abstract
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The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
First claim
Opening claim text (preview).
What is claimed is: 1. A composition comprising nanoparticles comprising a taxane coated with albumin and a ligand capable of binding a prion protein, wherein the nanoparticles in the composition have a negative zeta potential. 2. The composition of claim 1 , wherein the taxane is paclitaxel. 3. The composition of claim 1 , wherein the ligand is a peptide. 4. The composition of claim 1 , wherein the ligand is a triazine-based compound. 5. The composition of claim 1 , wherein the ligand is an antibody that recognizes a prion protein. 6. The composition of claim 5 , wherein the antibody is 3F4, 6H4, 16A18, ICSM-4, or ICSM-10. 7. The composition of claim 1 , wherein the ligand is a polymeric material that binds to prion proteins. 8. The composition of claim 7 , wherein the polymeric material comprises an amino group, a phenyl group, or a methacrylate backbone. 9. The composition of claim 1 , further comprising a supporting material. 10. The composition of claim 9 , wherein the supporting material is selected from the group consisting of a resin, a bead, and a membrane. 11. The composition of claim 1 , wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm. 12. A composition comprising nanoparticles comprising rapamycin coated with albumin and a ligand capable of binding a prion protein, wherein the nanoparticles in the composition have a negative zeta potential. 13. The composition of claim 12 , wherein the ligand is a peptide. 14. The composition of claim 12 , wherein the ligand is a triazine-based compound. 15. The composition of claim 12 , wherein the ligand is an antibody that recognizes a prion protein. 16. The composition of claim 15 , wherein the antibody is 3F4, 6H4, 16A18, ICSM-4, or ICSM-10. 17. The composition of claim 12 , wherein the ligand is a polymeric material that binds to prion proteins. 18. The composition of claim 17 , wherein the polymeric material comprises an amino group, a phenyl group, or a methacrylate backbone. 19. The composition of claim 12 , further comprising a supporting material. 20. The composition of claim 19 , wherein the supporting material is selected from the group consisting of a resin, a bead, and a membrane. 21. The composition of claim 12 , wherein the nanoparticles in the composition have an average diameter of no greater than about 200 nm.
Assignees
Inventors
Classifications
Antineoplastic agents · CPC title
Antivirals · CPC title
Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title
Protein · CPC title
Proteins, e.g. albumin, gelatin · CPC title
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Frequently asked questions
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- What does patent US10206887B2 cover?
- The present invention provides prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
- Who is the assignee on this patent?
- Abraxis Bioscience Llc
- What technology area does this patent fall under?
- Primary CPC classification A61K9/5169. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 19 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).