Sample concentration device

Patent metadata

Field	Value
Publication number	US-10203308-B2
Application number	US-201414760254-A
Country	US
Kind code	B2
Filing date	Jan 15, 2014
Priority date	Jan 18, 2013
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

A controller for controlling the operations of an autosampler, a sample push unit, and a make-up unit includes a pump stop timing setting unit for setting a first timing T1 of completion of dilution of a sample, and a subsequent second timing T2 of completion of trapping of a sample in the trap column, a dilution control unit for causing a solvent delivery pump for make-up of the make-up unit to operate, and for stopping operation of the solvent delivery pump for make-up at the first timing T1 set by the pump stop timing setting unit, and a sample push control unit for causing a solvent delivery pump for sample push of the sample push unit to operate, and for stopping operation of the solvent delivery pump for sample push at the second timing T2 set by the pump stop timing setting unit.

First claim

The invention claimed is:

1. A sample concentration device comprising:
an autosampler for injecting a certain volume of sample;
a trap column configured to trap the sample so that the sample is concentrated;
a sample push unit for delivering a sample injected by the autosampler to the trap column by a solvent delivery pump for sample push;
a make-up unit configured to send a diluent by a solvent delivery pump so that the diluent is merged to a sample pushed out by the sample push unit at a merging point provided upstream of the trap column; and
a controller configured to control operations of the autosampler, the sample push unit, and the make-up unit,
wherein the controller comprises
a pump stop timing setting unit for setting a first timing T 1 of completion of dilution of a sample, and a subsequent second timing T 2 of completion of trapping of a sample in the trap column,
a dilution control unit for causing the solvent delivery pump for make-up of the make-up unit to operate, and for stopping operation of the solvent delivery pump for make-up at the first timing T 1 set by the pump stop timing setting unit, and
a sample push control unit for causing the solvent delivery pump for sample push of the sample push unit to operate, and for stopping operation of the solvent delivery pump for sample push at the second timing T 2 set by the pump stop timing setting unit,

wherein the pump stop timing setting unit sets a timing calculated based on a sample sweep volume as the second timing T 2 , and
the sample sweep volume is the volume necessary for the end of a tailing portion of a sample bulk to pass from the merging point through the inside of the trap column and for the sample to be fixed to the trap column.

2. The sample concentration device according to claim 1 , wherein the pump stop timing setting unit sets a timing calculated based on a sample injection volume as the timing T 1 .

3. The sample concentration device according to claim 2 , wherein the controller is configured to swiftly stop a time program and end a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T 2 .

4. The sample concentration device according to claim 1 , wherein the pump stop timing setting unit stores in advance a timing T 1 calculated based on a maximum sample injection volume and a timing T 2 calculated based on the sample sweep volume, and when notified of a sample injection volume by the autosampler, calculates a timing T 1 based on the notified sample injection volume and takes the timing T 1 as a set value of the timing T 1 , and when not notified of a sample injection volume by the autosampler, takes the timing T 1 stored in advance as a set value.

5. The sample concentration device according to claim 4 , wherein the controller is configured to swiftly stop a time program and end a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T 2 .

6. The sample concentration device according to claim 1 , comprising
a probe for detecting a sample bulk end at a stage preceding the trap column,
wherein the pump stop timing setting unit sets a timing calculated based on a timing of a detection signal of the probe as the timing T 1 .

7. The sample concentration device according to claim 6 , wherein the controller is configured to swiftly stop a time program and end a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T 2 .

8. The sample concentration device according to claim 1 , wherein the controller is configured to swiftly stop a time program and end a concentration operation after stopping operation of the solvent delivery pump for sample push at the second timing T 2 .

Assignees

• Shimadzu Corp

Inventors

• Morikawa Tsuyoshi
• Okada Kohji

Classifications

• G01N2030/027

  Liquid chromatography · CPC title

• G01N30/24 Primary

  Automatic injection systems · CPC title

• G01N2033/0019

  Physics · mapped topic

• G01N30/7233

  interfaced to liquid or supercritical fluid chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• G01N30/84 Primary

  Preparation of the fraction to be distributed · CPC title