Gas dispersion manufacture of nanoparticulates, and nanoparticulate-containing products and processing thereof

Patent metadata

Field	Value
Publication number	US-10201916-B2
Application number	US-201314056134-A
Country	US
Kind code	B2
Filing date	Oct 17, 2013
Priority date	Aug 7, 2004
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

In one aspect, the present invention relates to a method of making multi-phase particles that include nanoparticulates and matrix, which maintains the nanoparticulates in a dispersed state. A flowing gas dispersion is generated that includes droplets of a precursor medium dispersed in a gas phase. The precursor medium contains liquid vehicle and at least a first precursor to a first material and a second precursor to a second material. The multi-phase particles are formed from the gas dispersion by removing at least a portion of the liquid vehicle from the droplets of precursor medium. The nanoparticulates in the multi-phase particles include the first material and the matrix in the multi-phase particles includes the second material.

First claim

What is claimed is:

1. A gas dispersion method for making nanoparticulates, the method comprising: generating a flowing gas dispersion, as generated the gas dispersion comprising droplets of a precursor medium dispersed in a gas phase, with the precursor medium comprising liquid vehicle and at least two precursors, a first said precursor being a precursor to a first material and a second said precursor being a precursor to a second material, the second material being a surface-modifying material comprising a dispersing agent capable of inhibiting agglomeration and promoting dispersion of nanoparticulates in a dispersion medium; in the gas dispersion, forming particles dispersed in the gas phase, the particles dispersed in the gas phase each comprising the second material and nanoparticulates that include the first material; the forming particles comprising removing at least a portion of the liquid vehicle from the droplets; wherein, the particles are decomposable in a liquid dispersion medium to release the nanoparticulates from the particles for dispersion of the nanoparticulates in the liquid dispersion medium; and wherein, when the particles are decomposed in and the nanoparticulates are dispersed in the liquid dispersion medium, at least a portion of the second material modifies a surface of the dispersed nanoparticulates, wherein the second material is chemically reactable with the nanoparticulates to functionalize the surface of the nanoparticulates.

2. A gas dispersion method for making nanoparticulates, the method comprising: generating a flowing gas dispersion, as generated the gas dispersion comprising droplets of a precursor medium dispersed in a gas phase, with the precursor medium comprising liquid vehicle and at least two precursors, a first said precursor being a precursor to a first material and a second said precursor being a precursor to a second material, the second material being a surface-modifying material comprising a dispersing agent capable of inhibiting agglomeration and promoting dispersion of nanoparticulates in a dispersion medium; in the gas dispersion, forming particles dispersed in the gas phase, the particles dispersed in the gas phase each comprising the second material and nanoparticulates that include the first material; the forming particles comprising removing at least a portion of the liquid vehicle from the droplets; wherein, the particles are decomposable in a liquid dispersion medium to release the nanoparticulates from the particles for dispersion of the nanoparticulates in the liquid dispersion medium; and wherein, when the particles are decomposed in and the nanoparticulates are dispersed in the liquid dispersion medium, at least a portion of the second material modifies a surface of the dispersed nanoparticulates, wherein after the forming particles, the method comprises: decomposing the particles in the liquid dispersion medium; and in the liquid dispersion medium, releasing the nanoparticulates from the particles, wherein during or after the decomposing, the method comprises: reacting the second material with the nanoparticulates to functionalize a surface of the nanoparticulates.

Assignees

• Sicpa Holding Sa

Inventors

• Kodas Toivo T
• Hampden-Smith Mark J
• Kunze Klaus
• Dericotte David E
• Vanheusden Karel
• Stump Aaron

Classifications

• B01J13/0043 Primary

  containing elemental metal (for medical or diagnostical purposes A61K, G01N) · CPC title

• B29B9/12 Primary

  characterised by structure or composition · CPC title

• B01J13/0095

  Preparation of aerosols · CPC title

• B01J13/0047

  containing a metal oxide · CPC title