Magnetic nanostimulator and nanosensor array for biological material stimulation and sensing

Patent metadata

Field	Value
Publication number	US-10201715-B2
Application number	US-201615130371-A
Country	US
Kind code	B2
Filing date	Apr 15, 2016
Priority date	Apr 15, 2015
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

An apparatus includes a substrate and a plurality of biological material stimulators positioned on the substrate. Each biological material stimulator forms a fluctuating magnetic field capable of inducing a current in biological material.

First claim

What is claimed is:

1. An apparatus comprising:
a substrate;
a plurality of biological material stimulators positioned on the substrate, each biological material stimulator forming a fluctuating magnetic field capable of interacting with biological material wherein each biological material stimulator comprises a magnetic structure in which a magnetic domain wall moves to produce the fluctuating magnetic field.

2. The apparatus of claim 1 wherein each biological material stimulator comprises a neuron stimulator capable of inducing a current in a neuron.

3. The apparatus of claim 1 wherein each biological material stimulator is controlled using light.

4. The apparatus of claim 1 further comprises at least one magnetic sensor positioned on the substrate and capable of determining when a neuron fires based on a magnetic field induced by the neuron.

5. The apparatus of claim 1 wherein the substrate is flexible.

6. The apparatus of claim 1 further comprising a power source and a wireless communication system positioned on the substrate.

7. A method comprising:
introducing an array of biological material stimulators mounted on a substrate into a living body;
applying signals to the array of biological material stimulators to cause the biological material stimulators to generate a fluctuating magnetic field that interacts with biological material surrounding the biological material stimulators wherein each biological material stimulator comprises a magnetic material and wherein each signal applied to each respective biological material stimulator causes at least one magnetic domain wall in the magnetic material of the respective biological material stimulator to move.

8. The method of claim 7 wherein the substrate is flexible.

9. The method of claim 7 wherein each biological material stimulator comprises a half loop of the magnetic material that extends upward from the substrate.

10. The method of claim 9 wherein each half loop of magnetic material has a height and at least two of the half loops of magnetic material have different heights from each other.

11. The method of claim 7 wherein introducing the biological material stimulators further comprises introducing a magnetic sensor mounted on the substrate with the biological material stimulators.

12. The method of claim 11 wherein the magnetic sensor comprises a magnetic tunnel junction.

13. The method of claim 7 wherein introducing the array of biological material stimulators comprises sealing the array of biological material stimulators in the living body without a wired connection between the array of biological material stimulators and an environment external to the living body.

14. A neuron stimulator comprising:
a substrate having an outer surface;
a magnetic nanowire extending transverse to the outer surface such that a top of the nanowire is above the substrate, the magnetic nanowire having at least two magnetic domains with at least one moveable domain wall between the magnetic domains.

15. The neuron stimulator of claim 14 wherein the substrate is flexible.

16. The neuron stimulator of claim 14 wherein the magnetic nanowire is one of a plurality of magnetic nanowires extending transverse to the outer surface.

17. The neuron stimulator of claim 16 wherein at least two of the plurality of magnetic nanowires extend different heights above the outer surface relative to each other.

18. The neuron stimulator of claim 14 further comprising a wireless power circuit capable of receiving power wirelessly.

19. The neuron stimulator of claim 14 further comprising at least one magnetic sensor positioned on the substrate.

20. The neuron stimulator of claim 19 further comprising a wireless communication system positioned on the substrate such that a sensed value from the at least one magnetic sensor is communicated through the wireless communication system to an external device.

Assignees

• Univ Minnesota

Inventors

• Wang Jian-Ping
• Low Walter C
• Dc Mahendra

Classifications

• A61N2/006 Primary

  for magnetic stimulation of nerve tissue · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title