Bicyclic compound and use thereof for medical purposes

Patent metadata

Field	Value
Publication number	US-10201520-B2
Application number	US-201715852493-A
Country	US
Kind code	B2
Filing date	Dec 22, 2017
Priority date	Jul 28, 2009
Publication date	Feb 12, 2019
Grant date	Feb 12, 2019

Abstract

Since a compound represented by the general formula (I) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.

First claim

The invention claimed is:

1. 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl}butanoic acid.

2. A pharmaceutical composition containing 4-{(3S,5aR,6R,7R,8aS)-6-1(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl}butanoic acid and a pharmaceutically acceptable carrier.

3. The pharmaceutical composition according to claim 2 , wherein a dosage form is an eye drop.

4. A method of treating an ocular disease, comprising administering an effective amount of 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl}butanoic acid to a mammal.

5. The method according to claim 4 , wherein the ocular disease is glaucoma, ocular hypertension, macular edema, macular degeneration, retina and optic nerve tensile force rise, myopia, hypermetropia, astigma, dry eye, amotio retinae, cataract, intraocular pressure rise due to trauma or inflammation, intraocular pressure rise due to a drug, or intraocular pressure rise after operation.

6. The method according to claim 4 , wherein the ocular disease is glaucoma, or ocular hypertension.

Assignees

• Ono Pharmaceutical Co

Inventors

• Kambe Tohru
• Maruyama Toru
• Yamane Shinsaku
• Nakayama Satoshi
• Tani Kousuke

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P27/12

  for cataracts · CPC title

• A61P27/10

  for accommodation disorders, e.g. myopia · CPC title

• A61P27/06

  Antiglaucoma agents or miotics · CPC title

• A61P27/02

  Ophthalmic agents · CPC title