Base material comprising hydrophilic layer

Patent metadata

Field	Value
Publication number	US-10197568-B2
Application number	US-201214130047-A
Country	US
Kind code	B2
Filing date	Apr 16, 2012
Priority date	Jun 28, 2011
Publication date	Feb 5, 2019
Grant date	Feb 5, 2019

Abstract

This invention provides a base material comprising a plastic-containing support and, on its surface, a hydrophilic layer comprising an ethylene glycol chain (an EG chain) composed of one or more ethylene glycol units, as well as a method for producing such base material. A polysiloxane-containing primer layer is provided on the support comprising a plastic material on its surface, and the EG chain is covalently bound to a polysiloxane side chain of the primer layer. Thus, a hydrophilic layer comprising the EG chain can be provided on the surface of the plastic-containing support.

First claim

We claim:

1. A base material comprising at least:
a support containing polystyrene on its surface;
a polysiloxane-containing primer layer on the surface of the support, wherein the polysiloxane-containing primer layer comprises a hydrolyzed form of 3-glycidoxypropyltrimethoxysilane or 3-glycidoxypropyltriethoxysilane and wherein the primer layer is bound to the surface of the support by Van der Waals force or hydrophobic interaction between the polystyrene and 3-glycidoxypropyl groups of the primer layer; and
on the primer layer, a hydrophilic layer containing an ethylene glycol chain with a number average molecular weight from 2,700 to 12,500, wherein one end of the ethylene glycol chain is covalently bound to other 3-glycidoxypropyl groups of the primer layer and the other end of the ethylene glycol chain is bound to a functional group selected from a (1H-imidazol-1-yl)carbonyl group or a succinimidyloxycarbonyl group, wherein the nitrogen concentration in the hydrophilic layer is from 0.010 to 0.050 when the functional group is a succinimidyloxycarbonyl group relative to a carbon concentration resulting from the C—O bonds in the hydrophilic layer being 1 and the nitrogen concentration in the hydrophilic layer is from 0.020 to 0.100 when the functional group is a (1H-imidazol-1-yl)carbonyl group relative to a carbon concentration resulting from the C—O bonds in the hydrophilic layer being 1.

2. A method for producing the base material according to claim 1 .

Assignees

• Ookouchi Norihiko
• AYAME Hirohito
• Tanaka Yuichi
• Watanabe Hiroko
• Dainippon Printing Co Ltd

Inventors

• Ookouchi Norihiko
• AYAME Hirohito
• Tanaka Yuichi
• Watanabe Hiroko

Classifications

• G01N33/54353 Primary

  with ligand attached to the carrier via a chemical coupling agent (coatings G01N33/54393) · CPC title

• G01N33/54393 Primary

  Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding · CPC title