MCL-1 inhibitors and methods of use thereof
US-9840518-B2 · Dec 12, 2017 · US
MCL-1 inhibitors and methods of use thereof
US10196404B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10196404-B2 |
| Application number | US-201715790660-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 23, 2017 |
| Priority date | Apr 22, 2016 |
| Publication date | Feb 5, 2019 |
| Grant date | Feb 5, 2019 |
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- Title
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- Abstract
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Abstract
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Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions of 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid, and enantiomers and pharmaceutically acceptable salts thereof, and methods of treating cancer with such compounds and compositions.
First claim
Opening claim text (preview).
The invention claimed is: 1. A compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) or a pharmaceutically acceptable salt thereof. 2. The compound of claim 1 . 3. The pharmaceutically acceptable salt of the compound of claim 1 . 4. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof and a pharmaceutical excipient, carrier or diluent.
Assignees
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Classifications
specific for leukemia · CPC title
Antineoplastic agents · CPC title
- C07D515/22Primary
in which the condensed system contains four or more hetero rings · CPC title
- C07D497/22Primary
in which the condensed system contains four or more hetero rings · CPC title
having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins · CPC title
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- What does patent US10196404B2 cover?
- Disclosed is a compound which is 17-chloro-5,13,14,22-tetramethyl-28-oxa-2,9-dithia-5,6,12,13,22-pentaazaheptacyclo[27.7.1.1 4,7 .0 11,15 .0 16,21 .0 20,24 .0 30,35 ]octatriaconta-1(37),4(38),6,11,14,16,18,20,23,29,31,33,35-tridecaene-23-carboxylic acid (Formula I) and enantiomers and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical composi…
- Who is the assignee on this patent?
- Astrazeneca Ab
- What technology area does this patent fall under?
- Primary CPC classification C07D515/22. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).