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Use of CPNE7 for differentiating non-dental mesenchymal stem cells into odontoblasts, regenerating dental pulp and treating dentin hypersensitivity
US10195246B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10195246-B2 |
| Application number | US-201615381984-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 16, 2016 |
| Priority date | Jun 19, 2014 |
| Publication date | Feb 5, 2019 |
| Grant date | Feb 5, 2019 |
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Abstract
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The present invention relates to: composition for differentiating non-dental mesenchymal stem cells into odontoblasts comprising CPNE7 protein or gene; method for differentiating in vitro non-dental mesenchymal stem cells using the same; and also use thereof.
First claim
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What is claimed is: 1. A method of treating dentin hypersensitivity comprising: administering to a subject in need thereof an effective amount of (i) an isolated CPNE7 protein or a gene encoding the same; (ii) a cell overexpressing a CPNE7 protein; (iii) a mesenchymal stem cell overexpressing a CPNE7 protein; (iv) an odontoblast differentiated from the mesenchymal stem cell of (iii); or (v) the isolated CPNE7 protein or gene of (i) in combination with a mesenchymal stem cell, thereby treating the dentin hypersensitivity in the subject, wherein the (i), (ii), (iii), (iv), or (v) further comprises MTA (Mineral Trioxide Aggregate) or calcium hydroxide (Ca(OH) 2 ). 2. The method of claim 1 , wherein the cell overexpressing a CPNE7 protein is a mesenchymal stem cell. 3. The method of claim 2 , wherein the mesenchymal stem cell is of non-dental origin. 4. A method of generating reactionary pulp in an affected area comprising: treating the affected area with an effective amount of (i) an isolated CPNE7 protein or a gene encoding the same; (ii) a cell overexpressing a CPNE7 protein; (iii) a mesenchymal stem cell overexpressing a CPNE7 protein; (iv) an odontoblast differentiated from the mesenchymal stem cell of (iii); or (v) the isolated CPNE7protein or the gene of (i) in combination with a mesenchymal stem cell, thereby generating reactionary pulp in the affected area, wherein the (i), (ii), (iii), (iv) or (v) further comprises MTA (Mineral Trioxide Aggregate) or calcium hydroxide (Ca(OH) 2 . 5. The method of claim 4 , wherein the cell overexpressing a CPNE7 protein is a mesenchymal stem cell. 6. The method of claim 5 , wherein the mesenchymal stem cell is of non-dental origin. 7. A method of regenerating dentin or pulp in an affected area comprising: treating the affected area with an effective amount of (i) an isolated CPNE7 protein or a gene encoding the same; (ii) a cell overexpressing a CPNE7 protein; (iii) a mesenchymal stem cell overexpressing a CPNE7 protein; (iv) an odontoblast differentiated from the mesenchymal stem cell of (iii); or (iv) the isolated CPNE7 protein or gene of (i) in combination with a mesenchymal stem cell, thereby regenerating the dentin or pulp in the affected area, wherein the (i),(ii), (iii), (iv) or (v) further comprises MTA (Mineral Trioxide Aggregate) or calcium hydroxide (Ca(OH) 2 ). 8. The method of claim 7 , wherein the cell overexpressing a CPNE7 protein is a mesenchymal stem cell. 9. The method of claim 8 , wherein the mesenchymal stem cell is of non-dental origin. 10. A method of indirect pulp capping in an affected area comprising: treating the affected area with an effective amount of (i) an isolated CPNE7 protein or gene encoding the same; (ii) a cell overexpressing a CPNE7 protein; (iii) a mesenchymal stem cell overexpressing a CPNE7 protein; (iv) an odontoblast differentiated from the mesenchymal stem cell of (iii); or (v) the isolated CPNE7 protein or the gene of (i) in combination with a mesenchymal stem cell, thereby performing indirect pulp capping in the affected area, wherein the (i), (ii), (iii), (iv) or (v) further comprises MTA (Mineral Trioxide Aggregate) or calcium hydroxide (Ca(OH) 2 ). 11. The method of claim 10 , wherein the cell overexpressing a CPNE7 protein is a mesenchymal stem cell. 12. The method of claim 11 , wherein the mesenchymal stem cell is of non-dental origin.
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- What does patent US10195246B2 cover?
- The present invention relates to: composition for differentiating non-dental mesenchymal stem cells into odontoblasts comprising CPNE7 protein or gene; method for differentiating in vitro non-dental mesenchymal stem cells using the same; and also use thereof.
- Who is the assignee on this patent?
- Seoul Nat Univ R&Db Foundation
- What technology area does this patent fall under?
- Primary CPC classification A61K38/1709. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 05 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).